| Japanese |
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| Title | 家兎VX-2腫瘍における99mTc-HMPAO腫瘍シンチグラフィの検討 |
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| Subtitle | 原著 |
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| Authors | 菅一能*, 内迫博路*, 本間穣*, 倉光達也*, 伊東克能*, 中木浩司*, 田中伸幸*, 有吉功*, 中西敬*, 宇津見博基**, 山田典将** |
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| Authors(kana) | |
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| Organization | *山口大学医学部放射線科, **附属病院放射線部 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 9 |
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| Page | 1049-1056 |
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| Year/Month | 1991/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」家兎下腿部の筋肉組織内に移植したVX-2腫瘍を用いて99mTc-HMPAOによる腫瘍シンチグラフィを施行し, これによる腫瘍血流の評価の可能性を検討した. 腫瘍部の99mTc-HMPAO静注直後の動態像と1時間後の静態像はほぼ同様のRI分布を示した. また腫瘍部の時間放射能曲線では静注後早期にピークを形成した後, 放射能の減少を示すが, その後はきわめて緩やかな減少を示すに留まり, 正常筋肉組織との高い放射能の差異を保持し, この間では腫瘍部/正常筋肉組織の放射能の比は時間の経過に係わらずほぼ一定値を示した. これらのことから99mTc-HMPAOにより腫瘍血流を定性的に評価し得ると考えられた. さらに99mTc-HMPAO静態像と腫瘍部のアンジオグラフィ所見および病理組織像との対比からも, 99mTc-HMPAOが腫瘍血流分布を反映することが示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-hexamethylpropyleneamine oxime, Tumor imaging, Blood flow. |
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| English |
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| Title | The Assessment of 99mTc-HMPAO Tumor Scintigraphy Using VX-2 Tumors in Rabbits |
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| Subtitle | Original Articles |
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| Authors | Kazuyoshi SUGA*, Hiromichi UCHISAKO*, Yuzuru HONMA*, Tatsuya KURAMITSU*, Katsuyoshi ITOH*, Kouji NAKAGI*, Nobuyuki TANAKA*, Isao ARIYOSHI*, Takashi NAKANISHI*, Hiromoto UTSUMI**, Norimasa YAMADA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, School of Medicine, Yamaguchi University, **Department of Radiology, Yamaguchi University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 9 |
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| Page | 1049-1056 |
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| Year/Month | 1991/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Tumor scintigraphy using 99mTc-hexamethyl-propyleneamine oxime (99mTc-HMPAO) was performed in VX-2 tumors implanted in the muscles of the lower limbs of rabbits to evaluate the possibility that this agent could be used to estimate the blood perfusion of the tumor. The distribution of 99mTc-HMPAO in the tumor immediately after the intravenous injection of this radiopharmaceutical exhibited almost the same distribution on the static image 1 hour after administration. Tumor time-activity curve for 99mTc-HMPAO revealed initial peak after the injection followed by fading of 99mTc-HMPAO activity and subsequent gradual decrease in activity over the next 1 hour. The ratio of 99mTc-HMPAO activity in the tumor to that in normal muscle tissue during this next 1 hour was high and independent of time. These findings indicate that static 99mTc-HMPAO scintigraphy can provide qualitative but not quantitative data useful in the estimation of tumor blood perfusion. Moreover, comparison of distribution of 99mTc-HMPAO on the static images and angiographic, histological findings also sug-gest that static 99mTc-HMPAO images accurately reflect tumor blood perfusion. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-hexamethylpropyleneamine oxime, Tumor imaging, Blood flow. |
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