| Japanese |
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| Title | 虚血性心疾患に対する99mTc-MIBIの診断能の評価 - 201Tlとの比較検討 - |
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| Subtitle | 原著 |
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| Authors | 高橋範雄*, 玉木長良*, 大谷弘*, 進藤真*, 河本雅秀*, 米倉義晴*, 小野晋司**, 野原隆司**, 神原啓文**, 河合忠一**, 小西淳二* |
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| Authors(kana) | |
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| Organization | *京都大学医学部放射線核医学科, **第三内科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 9 |
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| Page | 1021-1027 |
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| Year/Month | 1991/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」虚血性心疾患が疑われた27例を対象として, 運動負荷99mTc-hexakis 2-methoxy-2-isobutyl isonitrile(MIBI)SPECTを施行し, 冠動脈病変の検出能および虚血心筋の診断能について201Tlと比較検討を行った. 症例別のsensitivityは99mTc-MIBI, 201Tlともに94%(17/18), specificityは99mTc-MIBIが71%(5/7), 201Tlは57%(4/7)であった. 病変枝ごとのsensitivity, specificityは99mTc-MIBIがそれぞれ78%(21/27), 84%(32/38)に対し201Tlはそれぞれ74%(20/27), 82%(31/38)と, sensitivity, specificityとも99mTc-MIBIが僅かに高い値を示したが, ほぼ同等の診断能と考えられた. また, 安静時像あるいは遅延像での"再分布"の有無も88%(22/25)の症例, および94%(117/125)の区域において所見は一致していた. 不一致はPTCA, CABGなどの血流改善術後の症例に多くみられ, 両薬剤の集積機序の違いを反映しているものと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Emission computed tomography, 99mTc-MIBI, Thallium-201, Coronary artery disease, Myocardial perfusion. |
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| English |
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| Title | Comparison of 99mTc-Hexakis 2-Methoxy-2-Isobutyl Isonitrile and 201Tl SPECT Imaging for Evaluation of Coronary Artery Disease |
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| Subtitle | Original Articles |
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| Authors | Norio TAKAHASHI*, Nagara TAMAKI*, Hiroshi OHTANI*, Makoto SHINDO*, Masahide KAWAMOTO*, Yoshiharu YONEKURA*, Shinji ONO**, Ryuji NOHARA**, Hirofumi KAMBARA**, Chuichi KAWAI**, Junji KONISHI* |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, **Third Division, Department of Internal Medicine, Kyoto University Faculty of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 9 |
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| Page | 1021-1027 |
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| Year/Month | 1991/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]To evaluate clinical value of 99mTc-hexakis 2-methoxy-2-isobutyl isonitrile (MIBI) imaging for assessing coronary artery disease (CAD), 99mTc-MIBI SPECT imaging at post-exercise and at rest was compared with 201Tl SPECT imaging at post-exercise and 3 hours redistribution in 27 patients suspected with CAD. The sensitivities for detecting CAD patients were 94% (17/18) by both studies. The specificities were 71 % (5/7) by 99mTc-MIBI and 57% (4/7) by 201Tl (p=NS). The sensitivities for detecting stenosed coronary arteries (>=75% stenosis) were also similar between 99mTc-MIBI (78%) and 201Tl (74%) (p=NS). The similar specificity values were obtained by 99mTc-MIBI (84%) and by 201Tl (82%) (p=NS). The patterns of abnormality (normal, ischemia and scar) were similar between 99mTc-MIBI and 201Tl images in 22 of the 25 cases (88%) and 117 of the 125 segments (94%). However, these patterns were occasionally different particularly in patients who received PTCA or CABG. Thus, 99mTc-MIBI SPECT imaging seems to be as accurate as 201Tl SPECT imaging for the detecting and evaluating CAD. |
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| Practice | Clinical medicine |
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| Keywords | Emission computed tomography, 99mTc-MIBI, Thallium-201, Coronary artery disease, Myocardial perfusion. |
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