Japanese
TitleN-Isopropyl- [123I］ p-Iodoamphetamine (IMP) を使用したSPECTによる非侵襲的脳血流量定量法
Subtitle原著
Authors荒木有三*, 今井秀*, 宇野俊郎*, 今尾幸則*, 安藤隆*, 坂井昇*, 山田弘*
Authors(kana)
Organization*岐阜大学医学部脳神経外科
Journal核医学
Volume28
Number9
Page1013-1019
Year/Month1991/9
Article原著
Publisher日本核医学会
Abstract「要旨」種々の脳疾患24例を対象にIMP-SPECTを施行し, 簡便な脳血流量定量法を考案した. 撮像開始時間がIMP静注後平均20.6±1.2分のE2 imageと平均236.6±22.4分のD2 imageにおける正常脳皮質の摂取計数値の比(E2/D2)とXe-SPECTで測定した局所脳血流量(Xe-rCBF)を比較したところ, 比較的良好な相関が得られた. Xe-rCBF(y)とE2/D2(x)の相関式はy=68.2x-14.9, 相関係数はr=0.810, 推定値の標準誤差は5.6ml/100g/minであった. したがって, この相関式を使用して, E2/D2からrCBFを推定することが可能であった. また, IMPの正常脳のλ, 動脈血中濃度の変化パターンおよび約20分以降の動脈血中濃度が一定であり, 投与後早期には脳組織よりの逆拡散が無視できるとすると, rCBFはE/D(early imageとdelayed imageの脳摂取計数値の比)の一次式で示され, E/DよりrCBFを推定する方法は理論的にも妥当なものと考えられた.
Practice臨床医学：一般
Keywords123I-IMP, SPECT, Non-invasive quantitative measurement of CBF, 133Xe.
English
TitleA Non-Invasive Quantitative Measurement of Cerebral Blood Flow Using N-Isopropyl- [123I] p-Iodoamphetamine and Single Photon Emission CT
SubtitleOriginal Articles
AuthorsYuzo ARAKI, Shu IMAI, Toshiro UNO, Yukinori IMAO, Takashi ANDO, Noboru SAKAI, Hiromu YAMADA
Authors(kana)
OrganizationDepartment of Neurosurgery, Gifu University School of Medicine
JournalThe Japanese Journal of nuclear medicine
Volume28
Number9
Page1013-1019
Year/Month1991/9
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]A non-invasive quantitative method using N-isopropyl-[123I]p-iodoamphetamine (IMP) was described for assessing regional cerebral blood flow (rCBF). Twenty four cases, composed of 11 patients with brain tumors, 9 patients having cerebrovascular disease and 4 other patients aged 15-73 years, all underwent the SPECT 133Xe inhalation method (Xe-SPECT) and IMP-SPECT using a Tomomatic 564. In the IMP-SPECT cases, 111-222 MBq (3-6 mCi) of IMP was injected intravenously and then sequential imaging was performed 9.5 +- 1.2 (mean +- SD) min (E1 image), 20.6 +- 1.2 min (E2 image), 227.5 +- 22.1 min (D1 image), and 236.6 +- 22.4 min (D2 image) after the injection. The IMP-uptake value (counts/pixel/sampling time) in the region of interest (ROI), which was chosen in the non-affected cortex in the middle cerebral artery territory (MCAC), was counted on each image (E1 value, E2 value, D1 value and D2 value) and the E1/D1 ratios and E2/D2 ratios were consequently calculated. On the other hand, the absolute value of the ROI rCBF (Xe-rCBF) was obtained by Xe-SPECT. There were significant correlations noted between both the E1/D1 ratios and the E2/D2 ratios, and the Xe-rCBFs. Those correlation coefficients were found to be: r=0.741 and 0.810 respectively. Based on this significant relationship, equations were deduced to involve the rCBF values by use of IMP-SPECT: y=Ax+B (y: rCBF, x: E1/D1 ratio (E2/D2 ratio), A=52.8 (68.2), B=6.3 (-14.9), where A and B indicate the slope and deviation of the regression line). The ratio of rCBF in the affected area and in the MCAC is proportional to the ratio of the IMP-uptake value in the affected area and in the MCAC in the E1 and E2 image, and the absolute values of rCBF in the affected area can be calculated. This simpler rCBF quantitative method was found to be clinically useful and non-invasive.
PracticeClinical medicine
Keywords123I-IMP, SPECT, Non-invasive quantitative measurement of CBF, 133Xe.

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