| Japanese |
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| Title | ダイナミックSPECTとN-isopropy-p-[123I]iodoamphetamineを用いた局所脳血流量および分配定数の新しい解析法 : - グラフプロット法による定量化の試み - |
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| Subtitle | 研究速報 |
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| Authors | 横井孝司*,**, 飯田秀博*, 菅野巌* |
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| Organization | *秋田県立脳血管研究センター放射線医学研究部, **島津製作所 医用第二技術部 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 7 |
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| Page | 791-796 |
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| Year/Month | 1991/7 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-IMPによる局所脳血流量および脳血液分配定数の定量化のために, 脳内の123I-IMPの挙動が2コンパートメントモデルに従うと仮定した, ダイナミックSPECTとグラフプロット法による新しい解析方法を開発した. すなわち, まずその基本微分方程式を時間積分して線形化し, 動脈血中IMP濃度積分値で割ることによって, ある時間での脳組織IMP濃度と動脈血中IMP濃度積分値の比 [Y (t) = Cb (t) / ∫toCa (s) ds)] と脳組織IMP濃度積分値と動脈血中IMP濃度積分値の比 [X (t) = ∫to Cb (s) ds / ∫to Ca (s) ds] の間には直線関係を得, X (t), Y (t) をグラフプロットすれば, その直線のY軸切片が局所脳血流量 (K1), 傾きが洗い出し係数 (k2), X軸切片が脳血液分配定数 (λ) を表すことを導きだした. 本法を正常人 (n = 4) のダイナミックSPECT測定で得られたデータに適用して, 局所脳血流量と分配定数を計算した. 灰白質ではK1 = 40.8±6.5ml/100g/min, λ = 28.8±5.3ml/g, 白質ではK1 = 29.1±4.7ml/100g/min, λ = 28.1±7.1ml/gであった. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, regional cerebral blood flow, partition coefficient, dynamic single photon emission computed tomography, 2-compartment model. |
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| English |
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| Title | New Analysis Algorithm for Regional Cerebral Blood Flow and Partition Coefficient with Dynamic SPECT and N-isopropyl-p-[123I]iodoamphetamine : - Graphical Plot Method - |
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| Authors | Takashi YOKOI*,**, Hidehiro IIDA*, Iwao KANNO* |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels - AKITA, **Department of Research for Medical Systems, Shimadzu Corporation |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 7 |
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| Page | 791-796 |
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| Year/Month | 1991/7 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We developed a new analysis algorithm based on multiple-time graphical plot to estimate the regional cerebral blood flow and partition coefficient using dynamic SPECT and N-isopropyl-p-[123I]iodoamphetamine (123I-IMP). By assuming the 2-compartment model of the kinetic for 123I-IMP, we derived a linear relationship between the ratio of the tissue activity concentration at the times to the time-integral arterial concentration at the respective times [Y (t) = Cb (t) / ∫toCa (s) ds)] and the ratio of the time-integral tissue concentration to the time-integral arterial concentration [X (t) = ∫to Cb (s) ds / ∫to Ca (s) ds], and demonstrated that the Y-intercept and X-intercept of the plot line represent the regional cerebral blood flow (K1) and partition coefficient (λ), respectively. The slope of the line represents a clearance constant k2. The present method was applied to data on four normal subjects measured by dynamic SPECT. Values of the K1 and Z for the gray matter were obtained 40.8 +- 6.5ml/100g/min and 28.8 +- 5.3ml/g, respectively, and the corresponding values for the white matter were 29.1 +- 4.7ml/100g/min and 28.1 +- 7.1ml/g. The new method enabled a rapid estimation of both K1 andλ. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, regional cerebral blood flow, partition coefficient, dynamic single photon emission computed tomography, 2-compartment model. |
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