| Japanese |
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| Title | 健常者における大脳皮質・深部領域間の機能的関連 |
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| Subtitle | 短報 |
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| Authors | 羽生春夫*, 新井久之*, 阿部晋衛*, 羽田野展由*, 勝沼英宇*, 鈴木孝成** |
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| Authors(kana) | |
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| Organization | *東京医科大学老年科, **放射線科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 7 |
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| Page | 779-783 |
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| Year/Month | 1991/7 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」健常成人22例の安静時における脳血流量の左右差から, 大脳皮質・深部領域間の関連について検討した. 脳血流測定には123I-IMPによるSPECTを用い, 左右差指数AI = (R - L) / (R + L) / 200 (%) (R : right side, L : left side) を指標とした. AIによる深部灰白質と大脳皮質における相関を求めると, 上部前頭葉皮質 (r = 0.54, p < 0.01) と頭頂葉皮質 (r = 0.58, p < 0.01) において有意な正の相関が得られ, また大脳皮質平均 (r = 0.48, p < 0.05) においても有意であった. 本成績から, 健常者の安静時においても大脳皮質・深部領域間には投射線維連絡を介した機能的関連の存在が示唆され, 特に, 上部前頭葉皮質や頭頂葉皮質と深部灰白質との関連が推測された. 「I. はじめに」機能的に連絡された緊密な神経回路網からなる中枢神経系では, 限局した病変においても神経線維連絡を介してさまざまな遠隔領域に影響が及ぶ. |
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| Practice | 臨床医学：一般 |
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| Keywords | Celebral cortex, Deep gray matter, Cerebral blood flow, SPECT, 123I-IMP. |
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| English |
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| Title | The Functional Relationship Between the Cerebral Cortex and Deep Brain Areas in Normal Individuals |
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| Subtitle | |
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| Authors | Haruo HANYU*, Hisayuki ARAI*, Shinei ABE*, Nobuyoshi HATANO*, Hideyo KATSUNUMA*, Takanari SUZUKI** |
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| Authors(kana) | |
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| Organization | *Department of Geriatric Medicine, **Department of Radiology, Tokyo Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 7 |
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| Page | 779-783 |
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| Year/Month | 1991/7 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Recent PET or SPECT studies have demonstrated a reduction of blood flow and metabolism in the cortex ipsilateral to a deep-seated lesion, and in the thalamus and / or basal ganglia ipsilateral to a cortical lesion. A close relationship between the cerebral cortex and deep areas of the brain has been shown in pathological conditions, presumably because of functional interconnections between the cortex and deeper area. The present study was designed to investigate the relationship of cerebral blood flow in the cerebral cortex to that in the deep gray mstter including the basal ganglia and the thalamus in normal subjects. Twenty-two healthy subjects were studied using SPECT with N-isopropyl-p-[123I]iodoamphetamine while in a resting state. The asymmetry index (AI) of blood flow in both the cerebral cortex and deep gray matter was calculated as follows ; AI = (R - L) / (R + L) / 200 (%) (R : right side, L : left side). The AI in deep gray matter was significantly correlated with the AI values in the upper frontal cortex (r = 0.54, p < 0.01), and parietal cortex (r = 0.58, p < 0.01), as well as the mean cortical hemispheric AI (r = 0.48, p < 0.05). Our results suggest the existence of a functional relationship between the cerebral cortex and deep areas not only in pathological conditions but also in the resting state in normal subjects. This functional relationship is likely to be mediated by neuronal mechanisms through the projectional fiber connections between the cortex and the deep gray matter. |
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| Practice | Clinical medicine |
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| Keywords | Celebral cortex, Deep gray matter, Cerebral blood flow, SPECT, 123I-IMP. |
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