| Japanese |
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| Title | 気管支閉塞家兎による123I-IMPの肺内動態機序の検討 |
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| Subtitle | 原著 |
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| Authors | 菅一能*, 有吉功*, 倉光達也*, 中西敬*, 宇津見博基**, 山田典将** |
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| Organization | *山口大学医学部放射線科, **山口大学医学部附属病院放射線部 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 7 |
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| Page | 759-765 |
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| Year/Month | 1991/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」N-isopropyl-p-123I-iodoamphetamine (123I-IMP) の肺内動態に及ぼす肺血流の影響について, バルーンカテーテルによる気管支閉塞家兎を用いて基礎的研究を行った. 気管支閉塞した末梢肺野で局所的低肺動脈血流域が9兎で得られ (99mTc-MAA肺シンチグラフィにより確認), これらの家兎ではいずれも, 123I-IMP肺シンチグラフィのDelayed distribution image上, この低肺血流域内に異常集積を認めた. Early distribution imageと比較すると, この間に正常肺に比較して低い放射能を示す部位が, 逆に正常肺に比較して高い集積を示すようになる現象が認められた. さらにこの異常集積部位では, 正常肺野に比較して123I-IMPの肺からの洗い出しが遅延していた. これらの実験結果は, われわれが先に報告した63例の臨床症例における所見と一致するものであり, 123I-IMPの肺内動態に肺動脈血流が深く関与すると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, 99mTc-MAA, Pulmonary perfusion, Bronchial obstruction. |
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| English |
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| Title | Experimental Study on the Mechanism of Intrapulmonary Kinetics of 123I-IMP in Balloon Occluded Bronchus of Rabbit |
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| Authors | Kazuyoshi SUGA*, Isao ARIYOSHI*, Tatsuya KURAMITSU*, Takashi NAKANISHI*, Hiromoto UTSUMI**, Norimasa YAMADA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Yamaguchi University School of Medicine, **Department of Radiology, Yamaguchi University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 7 |
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| Page | 759-765 |
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| Year/Month | 1991/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To investigate the mechanism of intrapulmonary kinetics of N-isopropyl-p-123I-iodoamphetamine (123I-IMP), we performed lung scanning with 123I-IMP in 13 rabbits in which a unilateral bronchus was occluded by a balloon catheter. In 9 rabbits, on the delayed distribution images, an abnormal accumulation of 123I-IMP was detected in the hypoperfusion area of the peripheral lung field of the occluded bronchus, which was detected on lung perfusion images with 99mTc-MAA. Comparison of early (a summation image during 20 seconds immediately after injection) and delayed (a summation image from 70 to 90 minutes after injection) distribution images confirmed that during this period, 123I-IMP accumulated in the area of reduced distribution of 123I-IMP. Moreover, at the site of abnormal accumulation, washout of 123I-IMP from the lung was delayed compared with that in the normal lung field. We find this experimental study is similar to the results in 63 clinical cases, which we have reported previously, and confirm that pulmonary arterial perfusion, especially hypoperfusion, influences the intrapulmonary kinetics of 123I-IMP. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, 99mTc-MAA, Pulmonary perfusion, Bronchial obstruction. |
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