| Japanese |
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| Title | 無症候性白質病変の脳血流量におよぼす影響 - 133Xe静注法およびMRIによる検討 - |
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| Subtitle | 原著 |
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| Authors | 井坂吉成, 石田麻里子, 中山博文, 芦田敬一, 今泉昌利, 古川俊之 |
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| Organization | 国立大阪病院循環器科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 7 |
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| Page | 737-742 |
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| Year/Month | 1991/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」MRI検査で白質病変が認められた無症候例32例において, 加齢による白質病変数, 脳血流量, 脳血管抵抗, 平均血圧の変化および白質病変数と平均血圧, 脳血流量, 脳血管抵抗の関係を検討した. 脳血流量は133Xe静注法により測定した. 脳血管抵抗は脳血流量測定時に聴診法で得られた平均血圧値を脳血流量で除して算出した. 加齢にともなって白質病変は増加 (r = 0.39 ; p <0.05), 脳血流量は減少 (r = -0.529 ; p < 0.01), 脳血管抵抗は上昇した (r = 0.464 ; p < 0.01). 白質病変数と脳血流量の間には負の相関関係 (r = -0.499 ; p < 0.01), 白質病変数と脳血管抵抗の間には正の相関関係 (r = 0.468 ; p < 0.01) が認められた. さらに脳血流量と白質病変数, 脳血管障害の危険因子, 脳血流量に影響を及ぼす生化学的変量との関係の多重回帰分析を行うと, 白質病変数は年齢とともに脳血流量に独立に影響を及ぼす重要な因子であることが判明した. すなわち白質病変数の多い例では脳血流量が低い傾向にあり, この現象は白質病変の成立の原因であるという解釈, あるいは白質病変が存在している結果を反映しているという解釈のいずれも成り立つと考えられた. 無症候例における白質病変の臨床的な意義づけと白質病変の脳血流量低下機序については, 白質病変を持たない健常例あるいは有症候例との比較を含めてさらなる検討が必要と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Cerebral blood flow, White matter lesions, MRI, Asymptomatic cerebral infarction, 133Xe. |
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| English |
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| Title | Effect of White Matter Lesions on Cerebral Blood Flow in Asymptomatic Individuals : Assessment by MRI and 133Xe-CBF Method |
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| Authors | Yoshinari ISAKA, Mariko ISHIDA, Hirofumi NAKAYAMA, Keiichi ASHIDA, Masatoshi IMAIZUMI, Toshiyuki FURUKAWA |
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| Authors(kana) | |
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| Organization | Department of Cardiovascular Medicine and Nuclear Medicine, Osaka National Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 7 |
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| Page | 737-742 |
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| Year/Month | 1991/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In 32 patients with asymptomatic white matter lesions (WMLs), we evaluated the age-related changes in the number of white matter lesions, cerebral blood flow (CBF), cerebrovascular resistance (CVR) and mean arterial blood pressure (MABP). CBF was measured with the intravenous 133Xe injection method. The number of WMLs in whole brain was measured by the magnetic resonance imaging. CBF decreased with advancing age (r = 0.529 ; p < 0.01),while the number of WMLs (r = 0.39 ; p < 0.05), CVR (r = 0.464 ; p < 0.01) and MABP (r = 0.229 ; ns) increased with advancing age. There was a significantly negative correlation (r = -0.499 ; p < 0.01) between CBF and the number of WMLs. While, CVR showed a positive correlation with the number of WMLs (r = 0.468 ; p < 0.01). Multivariate regression analysis with stepwise forward selection method indicated that the number of WMLs and age were indepedent and negative predictors for CBF, while other factors did not. CBF decreased with a concomitant rise in CVR. On the basis of the results listed above, we assumed that ischemic damage of the white matter and / or functional suppression of distant loci due to the primary tissue damage are the best explanation for CBF reduction in asymptomatic individuals with WMLs. High resolution CBF imaging as well as evaluation of structural alterations in cerebrovascular vessels should be required to further define the mechanisms. |
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| Practice | Clinical medicine |
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| Keywords | Cerebral blood flow, White matter lesions, MRI, Asymptomatic cerebral infarction, 133Xe. |
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