| Japanese |
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| Title | 99mTc-ECDによる脳血流SPECTイメージングの検討 |
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| Subtitle | 原著 |
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| Authors | 松田博史*, 絹谷啓子*, 東壮太郎**, 川崎康弘***, 隅屋寿*, 秀毛範至*, 久田欣一*, 山下純宏**, 山口成良*** |
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| Authors(kana) | |
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| Organization | *金沢大学医学部核医学科, **脳神経外科, ***神経精神科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 7 |
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| Page | 701-709 |
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| Year/Month | 1991/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」新しい脳血流SPECT用剤99mTc-ECDの基礎的・臨床的検討を行った. 放射化学的純度は調整後30分で98%前後とプラトーになり以後24時間以降も安定であった. 体内分布の検討では投与量の約5%が脳に集積し, 以後1時間あたり平均5.6%の割合で洗い出されたが, 他の部位の放射能は主に腎尿路系から, よりすみやかに排泄された. 脳内分布は投与2分で決定し, 以後1時間程度までほぼ一定であったが, 3時間以降では軽度ながら大脳皮質放射能の相対的低下, 灰白質 / 白質放射能比の低下, 白質および視床放射能の相対的増加が生じた. IMPおよびHMPAOによる脳血流像との比較では, 大脳および小脳皮質病変では健常部位との濃度コントラストがIMPよりも小さく, また視床および線条体病変ではIMPよりも大きく, いずれの部位においてもHMPAOよりはやや大きかった. また, 投与1時間前後が外頸動脈成分がすでに洗い出され, 濃度コントラストにも投与直後よりやや優れるので至適撮像時間と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ethyl cysteinate dimer, SPECT, Brain perfusion. |
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| English |
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| Title | Evaluation of Brain Perfusion SPECT Imaging Using 99mTc-ECD |
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| Subtitle | Original Articles |
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| Authors | Hiroshi MATSUDA*, Keiko KINUYA*, Sotaro HIGASHI**, Yasuhiro KAWASAKI***, Hisashi SUMIYA*, Noriyuki SHUKE*, Kinichi HISADA*, Junkoh YAMASHITA**, Nariyoshi YAMAGUCHI*** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurosurgery, ***Department of Neuropsychiatry, Kanazawa University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 7 |
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| Page | 701-709 |
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| Year/Month | 1991/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Fundamental and clinical evaluation was performed on 99mTc-ECD, that is a new agent for brain perfusion SPECT. Radiochemical purity reaches a plateau of approximately 98% at 30 min after reconstitution and remains stable up to 24 hours later. A biodistribution study showed approximately 5% injected dose in the brain, very slow brain washout of 5.6% per hour on the average, and rapid washout from the other organ mainly through the urinary system. Brain ECD distribution was determined within 2 min postinjection and remained stable for up to 1 hour. Three hours later, slight but significant changes in brain distribution were observed, that were relative reduction of cerebral cortical activity and gray to white matter activity ratio, and relative elevation of white matter and thalamic activities. Comparative studies of ECD images with IMP and HMPAO images revealed that radioactivity contrast between affected and unaffected areas was less prominent in ECD than in IMP in cerebral and cerebellar cortical lesions, more prominent in ECD than in IMP in striatal and thalamic lesions, and somewhat more prominent in ECD than in HMPAO in both lesions. Imaging around 1 hour postinjection seems to be more appropriate than immediate postinjection imaging because of the clearance of the extracranial radioactivity and somewhat better radioactivity contrast between affected and unaffected areas. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ethyl cysteinate dimer, SPECT, Brain perfusion. |
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