| Japanese |
|---|
| Title | Thyrotropin-releasing hormone (TRH) 負荷試験による血中プロラクチン濃度の速度論的解析 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 吉田泰子*, 川崎幸子*, 森川則文**, 田邉正忠*, 佐藤功*, 塚本豊久**, 中野節** |
|---|
| Authors(kana) | |
|---|
| Organization | *香川医科大学医学部附属病院放射線科, **薬剤部 |
|---|
| Journal | 核医学 |
|---|
| Volume | 28 |
|---|
| Number | 6 |
|---|
| Page | 585-590 |
|---|
| Year/Month | 1991/6 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」速度論解析を用いてプロラクチン分泌機構の推定を試みた. 健常男子にThyrotropin-releasing hormone (以下TRHと略) 500μgを肘静脈より投与しイムノラジオメリックアッセイにより血中プロラクチン濃度を測定した. TRH負荷によるプロラクチン分泌速度変化に対応する速度論モデルを構築し, 血中プロラクチン濃度解析を行った. 理論値と実測値は良く適合し (r = 0.995), モデルの妥当性が確認できた. TRH負荷後1.97±0.57分で分泌亢進が開始され12.7±2.1分で最高値となった. また, 負荷による総分泌量は75.4±18.4ng/mlであり, これは平常分泌量の4.3時間分に相当した. 解析により求めたプロラクチンの血中半減期は40.8±13.8分であり, これまでの報告とほぼ一致した. すでに報告したTRH負荷後におけるTSHの分泌機構と比較すると分泌開始はほとんど同時に起こるが, プロラクチンの方が短時間に放出を終えることが示めされた. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Prolactin secretion, TRH test, Kinetic model, Half-life. |
|---|
| English |
|---|
| Title | A Kinetic Study on Serum Prolactin Concentration in the Thyrotropin-Releasing Hormone Test |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Yasuko YOSHIDA*, Yukiko KAWASAKI*, Norifumi MORIKAWA**, Masatada TANABE*, Katashi SATOH*, Toyohisa TSUKAMOTO**, Misao NAKANO** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology, **Department of Pharmacy Kagawa Medical School |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 28 |
|---|
| Number | 6 |
|---|
| Page | 585-590 |
|---|
| Year/Month | 1991/6 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] In order to estimate the mechanism of prolactin secretion using the kinetic model, serum prolactin concentrations in normal young men were measured by an immunoradiometric assay before and after intravenous administration of 500μg of thyrotropin-releasing hormone (TRH). The kinetic model was applied to evaluate the secretion rate both before and after the administration of TRH. A good correlation between the calculated values and measured values of serum concentration was observed (r = 0.995) ; and the adequacy of the model was confirmed. A few minutes (1.97 +- 0.57 min) after the administration of TRH, the secretion of prolactin was stimulated, and serum prolactin concentration was maximum at 12.7 +- 2.1 min. The total amounts of secreted prolactin was 75.4 +- 18.4 ng/ml, which corresponded to the amount that was secreted in 4.3 hours at the normal rate. The half-life of prolactin was 40.8 +- 13.8 min, which is in good agreement with the previously reported values. We have already reported on the kinetic study on the TSH secretion after TRH. Comparing the concentration change of prolactin and TSH, which were reported previously, it was found that the stimulated secretion started almost simultaneously, but lasted longer with respect to TSH. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Prolactin secretion, TRH test, Kinetic model, Half-life. |
|---|