| Japanese |
|---|
| Title | 123I-IMPを用いた肺吸入シンチグラフィの試み |
|---|
| Subtitle | 原著 |
|---|
| Authors | 小須田茂*, 河原俊司**, 石橋章彦**, 田村宏平**, 久保敦司***, 橋本省三*** |
|---|
| Authors(kana) | |
|---|
| Organization | *都立駒込病院放射線診療科, **国立大蔵病院放射線科, ***慶応大学医学部放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 28 |
|---|
| Number | 6 |
|---|
| Page | 577-583 |
|---|
| Year/Month | 1991/6 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」肺胞上皮を経細胞性移行する脂溶性物質123I-IMPを用いて, エロソール吸入シンチグラフィを9症例に施行した. 健常人4例の検討では下肺野が最もクリアランスが速く, 以下, 中, 上肺野の順であった. ほぼ同時期に施行した99mTc-DTPAによるエロソール吸入スキャンでは1 compartmentの指数関数で近似できたのに対し, 123I-IMPは2相性の曲線を示し, 2 compartmentで比較的よく近似できた. 99mTc-DTPAでは健常群 (n = 4) より肺疾患群 (拘束性障害, n = 4) でk値は高値を示した (1.48±0.41×10-4 vs 2.18±0.30×10-4) のに対し, 123I-IMPではその逆で, 肺疾患群で低値を示し (1.52±0.45×10-3 vs 6.79±0.55×10-5), その差は99mTc-DTPAより大きかった. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 123I-IMP, 99mTc-DTPA, Aerosol scan, Restrictive ventilatory impairment. |
|---|
| English |
|---|
| Title | Pulmonary Inhalation Scintigraphy Using N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) Aerosol |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Shigeru KOSUDA*, Shunji KAWAHARA**, Akihiko ISHIBASHI**, Kohei TAMURA**, Atsushi KUBO***, Shozo HASHIMOTO*** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology, Tokyo Metropolitan Komagome Hospital, **Department of Radiology, Ohkura National Hospital, ***Department of Radiology, Keio University School of Medicine |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 28 |
|---|
| Number | 6 |
|---|
| Page | 577-583 |
|---|
| Year/Month | 1991/6 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] N-isopropyl-p[123I]iodoamphetamine (123I-IMP) is lipophilic substance and permeates through the alveolar epithelium via intracellular transport, whereas 99mTc-DTPA is water-soluble substance and permeates through the alveolar epithelium via paracellular transport. We performed inhalation lung imaging using 123I-IMP and 99mTc-DTPA in order to assess alveolar epithelial permeability in 4 patients with restrictive ventilatory impairment, and 5 volunteers including one smoker. The time-activity (T / A) curves of 123I-IMP were well fitted into two compartments, first and slow, by least-squares fit technique, in contrast to 99mTc-DTPA fitted well with one compartment. In 4 normal volunteers, the T / A curves of the lower pulmonary fields declined faster than those of other pulmonary fields. In 99mTc-DTPA studies, the Kep values of patients with restrictive ventilatory impairment (n = 4) were higher than those of normal volunteers (n = 4) (2.14 +- 0.30×10-4 vs 1.48 +- 0.41×10-4, p < 0.005). On the other hand, in 123I-IMP studies, the Kep values of the patients were much lower than those of normal volunteers (6.79 +- 0.55×10-5 vs 1.52 +- 0.45×10-3, p < 0.005). |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 123I-IMP, 99mTc-DTPA, Aerosol scan, Restrictive ventilatory impairment. |
|---|