| Japanese |
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| Title | 心臓における交感神経系診断用放射性医薬品123I-MIBGの臨床的評価について - 多施設による共同研究 - |
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| Subtitle | ≪原著≫ |
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| Authors | 廣澤弘七郎*, 田中健**, 久田欣一***, 分校久志*** |
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| Authors(kana) | |
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| Organization | *榊原記念病院顧問, **心臓血管研究所内科, ***金沢大学核医学科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 5 |
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| Page | 461-476 |
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| Year/Month | 1991/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」交感神経機能を反映した画像情報が得られるとされる123I-MIBGの心臓領域における臨床的有用性について, 多施設による共同研究を行った. 心疾患を有する患者を対象とし, 心筋梗塞群, 狭心症群, 心筋症群の3群に分け, 本剤の有効性を検討した. それぞれの群において, 123I-MIBGにより心臓の交感神経機能を反映した画像が得られると考えられた. 解析対象822症例中781症例(95.0%)にその有効性が示された. 同時期に施行された冠血流の指標である201TlCl心筋シンチグラフィとの対比では, 血流の正常な心筋においても, 交感神経機能異常が存在すると考えられ, 非常に興味深い結果が得られた. また, 本剤を投与された全981症例中4症例(0.4%)に血管痛, 悪心等の自他覚症状が認められた他は何ら異常はなく, 本剤の安全性の高いことが示された. 以上, 安全性, 有効性から判断した本剤の有用性は, 822症例中794症例(96.6%)に認められ, 本剤が心臓の局所交感神経機能の評価における有用な診断方法のひとつになるものと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-MIBG, 201Tl, heart disease, scintigraphy, sympathetic nervous system. |
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| English |
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| Title | Clinical Evaluation of 123I-MIBG for Assessment of Sympathetic Nervous System in the Heart (Multi-center Clinical Trial) |
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| Subtitle | - Original Articles - |
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| Authors | Koushitiro HIROSAWA*, Takeshi TANAKA**, Kin'ichi HISADA***, Hisashi BUNKO*** |
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| Authors(kana) | |
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| Organization | *Sakakibara Heart Institute, **The Cardiovascular Institute, Internal Medicine, ***Department of Nuclear Medicine, Kanazawa University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 5 |
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| Page | 461-476 |
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| Year/Month | 1991/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Multi-center clinical trial of 123I-metaiodobenzylguanidine (123I-MIBG) was carried out to assess its utility as a scintigraphic imaging agent reflecting sympathetic neuronal function in cardiovascular field. Studies were performed on patients with heart diseases of three categories, myocardial infarction, angina pectoris and cardiomyopathy. Scintigraphic images, reflecting sympathetic neuronal function were obtained with 123I-MIBG from all of those categories of patients and the efficacy of the imaging was revealed in 781 (95.0%) out of 822 patients. In some patients anormality was suggested in sympathetic neuronal function with 123I-MIBG imaging, in spite of normal findings with myocardial perfusion scintigraphy by 201TlCl. In all 981 patients studied with 123I-MIBG, there have been no severe adverse reactions, except complaints of burning on injection site of the agent or nausea, etc. from 4 patients. We conclude that 123I-MIBG imaging is one of the effective tools for diagnostic use reflecting topical sympathetic neuronal function in the heart, judging from its safety and efficacy. |
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| Practice | Clinical medicine |
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| Keywords | 123I-MIBG, 201Tl, heart disease, scintigraphy, sympathetic nervous system. |
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