| Japanese |
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| Title | 曲線回帰法による99mTc-DTPA-galactosyl human serum albuminの血中濃度評価 |
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| Subtitle | ≪研究速報≫ |
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| Authors | 河相吉*, 小島通真*, 菅豊*, 黒川弘晶*, 板垣康*, 田中敬正* |
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| Authors(kana) | |
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| Organization | *関西医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 4 |
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| Page | 425-428 |
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| Year/Month | 1991/4 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc標識DTPA-galactosyl-human serum albumin (99mTc-GSA)の臨床応用を行った. 健常者および肝疾患例計7例を対象に, 3〜10 mg/185 MBq (5 mCi)の99mTc-GSAを投与した. 肺野バックグラウンドを除去した心の時間放射能曲線に対し非線形最小2乗法を用いて指数関数回帰式を求め, これに外挿法を応用することにより, 99mTc-GSAの血中絶対値濃度曲線HR(t)を算出した. 2分以降の心測定値はほぼ回帰式と一致し, 回帰重相関係数は0.997±0.003 (mean±SD)と高い値を示した. 2〜60分間でのHR(t)とサンプル血より求めた経時的% Injected Dose (S(t))の各症例での偏差絶対値は平均1.7〜4.3%であり, 両者は良好な一致を示した. 本法は採血によらずして血中濃度を絶対量として算定可能とし非侵襲的かつ定量的なクリアランス指標が得られる点で有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Liver scintigraphy, Asialoglycoprotein receptor, Nonlinear regression analysis, Radiopharmaceuticals. |
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| English |
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| Title | Dose Estimation of Tc-99m-DTPA-galactosyl-human Serum Albumin (Tc-99m-GSA) in the Blood with Nonlinear Regresion Method |
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| Subtitle | - Rapid Communication - |
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| Authors | Sang Kil Ha-KAWA*, Michimasa KOJIMA*, Yutaka SUGA*, Hiroaki KUROKAWA*, Yasushi ITAGAKI*, Yoshimasa TANAKA* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Kansai Medical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 4 |
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| Page | 425-428 |
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| Year/Month | 1991/4 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Tc-99m-DTPA-galactosyl-human serum albumin (Tc-99m-GSA) was applied as an agent for receptor-binding hepatic scintigraphy. A single dose of 3-10 mg/185 MBq (5 mCi) Tc-99m-GSA per body was administered in four healthy volunteers and three patients. Time-activity curves for 60 (40) min after injection were obtained from the regions-of-interest over the heart and lung (background). Exponential regression curve was generated from the heart curve during 2-60 (40) min after background subtraction with nonlinear least squares method. Regression curve was well fitted to the heart curve and a significant correlation coefficient of 0.997 +- 0.003 was obtained between these two curves. Absolute dose of GSA in the blood was decided on the assumption that extrapolated value of regression curve at time 0 represented the total injected dose. The absolute dose differences between sample blood and regression curve were 1.4-4.3% (mean). Nonlinear regression analysis is useful for estimating quantitative dose of GSA in blood without any blood samples. |
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| Practice | Clinical medicine |
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| Keywords | Liver scintigraphy, Asialoglycoprotein receptor, Nonlinear regression analysis, Radiopharmaceuticals. |
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