Japanese
Title喫煙肺におけるIMP肺集積の実験的検討
Subtitle≪原著≫
Authors加藤邦彦*, 高橋恒男*, 柳澤融*
Authors(kana)
Organization*岩手医科大学放射線科
Journal核医学
Volume28
Number4
Page411-417
Year/Month1991/4
Article原著
Publisher日本核医学会
Abstract「要旨」非喫煙肺と喫煙肺におけるIMPの肺内動態の差異を雄モルモットを用い, 125I-IMPによるミクロオートラジオグラフィで比較検討した. 非喫煙肺では主に肺胞毛細血管, 肺胞上皮へ銀粒子の集積が見られたのに対し, 喫煙肺ではさらに肺胞腔および肺胞マクロファージにも多数の銀粒子の集積を認めた. そこで, 両群について気管支肺胞洗浄を行い, 洗浄液内の放射活性(カウント数)および肺胞マクロファージ数を比較したところ, 喫煙肺において放射活性(カウント数)および肺胞マクロファージの増加が認められた. このことから, 喫煙肺においてIMPの肺胞マクロファージへの集積増加とこれに伴うIMPの肺からの洗い出しの遅延が招来されると考えられた.
Practice臨床医学:一般
KeywordsN-isopropyl-p-iodoamphetamine (125I-IMP), Microautoradiography, bronchoalveolar lavage, Alveolar macrophage.
English
TitleExperimental Study on the Accumulation of 125I-IMP in the Cigarette-exposed Lung
Subtitle- Original Articles -
AuthorsKunihiko KATO, Tsuneo TAKAHASHI, Toru YANAGISAWA
Authors(kana)
OrganizationDepartment of Radiology, Iwate Medical University
JournalThe Japanese Journal of nuclear medicine
Volume28
Number4
Page411-417
Year/Month1991/4
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] In the experiment using guinea pigs, the accumulated portions of IMP after 125I-IMP microautoradiography were compared in a normal control group and a group exposed to cigarette smoke. In the smoke-exposed lung, the accumulation of silver grains were observed in the alveolar spaces and alveolar macrophages, as well as in the pulmonary capillaries and the alveolar epithelia. After the broncho-alveolar lavage (BAL), increases in alveolar macrophages, total counts of BAL fluid and counts of cell components were seen in the smoke-exposed lung. These results suggested that abnormal function of the pulmonary capillary or alveolar epithelium was wide spread in the smoke-exposed lung.
PracticeClinical medicine
KeywordsN-isopropyl-p-iodoamphetamine (125I-IMP), Microautoradiography, bronchoalveolar lavage, Alveolar macrophage.

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