| Japanese |
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| Title | 喫煙肺におけるIMP肺集積の実験的検討 |
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| Subtitle | ≪原著≫ |
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| Authors | 加藤邦彦*, 高橋恒男*, 柳澤融* |
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| Authors(kana) | |
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| Organization | *岩手医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 4 |
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| Page | 411-417 |
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| Year/Month | 1991/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」非喫煙肺と喫煙肺におけるIMPの肺内動態の差異を雄モルモットを用い, 125I-IMPによるミクロオートラジオグラフィで比較検討した. 非喫煙肺では主に肺胞毛細血管, 肺胞上皮へ銀粒子の集積が見られたのに対し, 喫煙肺ではさらに肺胞腔および肺胞マクロファージにも多数の銀粒子の集積を認めた. そこで, 両群について気管支肺胞洗浄を行い, 洗浄液内の放射活性(カウント数)および肺胞マクロファージ数を比較したところ, 喫煙肺において放射活性(カウント数)および肺胞マクロファージの増加が認められた. このことから, 喫煙肺においてIMPの肺胞マクロファージへの集積増加とこれに伴うIMPの肺からの洗い出しの遅延が招来されると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl-p-iodoamphetamine (125I-IMP), Microautoradiography, bronchoalveolar lavage, Alveolar macrophage. |
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| English |
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| Title | Experimental Study on the Accumulation of 125I-IMP in the Cigarette-exposed Lung |
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| Subtitle | - Original Articles - |
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| Authors | Kunihiko KATO, Tsuneo TAKAHASHI, Toru YANAGISAWA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Iwate Medical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 4 |
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| Page | 411-417 |
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| Year/Month | 1991/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In the experiment using guinea pigs, the accumulated portions of IMP after 125I-IMP microautoradiography were compared in a normal control group and a group exposed to cigarette smoke. In the smoke-exposed lung, the accumulation of silver grains were observed in the alveolar spaces and alveolar macrophages, as well as in the pulmonary capillaries and the alveolar epithelia. After the broncho-alveolar lavage (BAL), increases in alveolar macrophages, total counts of BAL fluid and counts of cell components were seen in the smoke-exposed lung. These results suggested that abnormal function of the pulmonary capillary or alveolar epithelium was wide spread in the smoke-exposed lung. |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl-p-iodoamphetamine (125I-IMP), Microautoradiography, bronchoalveolar lavage, Alveolar macrophage. |
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