Japanese
Title直接積分線形最小2乗法による簡便なヘパトグラム解析法の開発 (第2報) - 臨床上の有用性について (170例での検討) -
Subtitle≪原著≫
Authors秀毛範至*
Authors(kana)
Organization*金沢大学医学部核医学教室
Journal核医学
Volume28
Number4
Page391-400
Year/Month1991/4
Article原著
Publisher日本核医学会
Abstract「要旨」170例の肝胆道シンチグラムを対象に直接積分線形最小2乗法を用いてコンパートメントモデル解析を行い, 得られたモデルパラメータ値の臨床的意義を, モデルパラメータ値とシンチグラムの定性的評価との対比, および, 肝機能検査データとの対比により検討した. その結果, 各モデルパラメータ値は, 視覚的所見と良好な対応を示し, 肝機能検査データとも有意な相関を示した. 以上の検討より, この解析法の臨床上の有用性が確認されたので, この方法の簡便性を生かし, 肝内局所の機能分布評価の目的でパラメータ画像を作製した. 本法は局所肝機能の定量評価を可能にする有用な方法と考えられた.
Practice臨床医学：一般
KeywordsHepatobiliary scintigraphy, Hepatogram analysis, Direct integral linear least square regression method.
English
TitleDirect Integral Linear Least Square Regression Method for Kinetic Evaluation of Hepatobiliary Scintigraphy : Clinical Application and Evaluation of 170 Hepatograms
Subtitle- Original Articles -
AuthorsNoriyuki SHUKE
Authors(kana)
OrganizationDepartment of Nuclear Medicine, Kanazawa University School of Medicine
JournalThe Japanese Journal of nuclear medicine
Volume28
Number4
Page391-400
Year/Month1991/4
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Kinetic evaluation of 170 hepatobiliary scintigrams was performed using direct integral linear least square regression method (DILS method). Liver time-activity curve (TAC) data were fitted to 2 types of 1 compartment model using heart TAC as input function. One model was 1 compartment model with 2 parameters (extraction rate (ku) and excretion rate (ke)), the other had another parameter for representing non-specific volume of distribution (Vn) in liver. Obtained parameter estimate was then examined to see how they correlate with three major visual findings of scintigram; low tracer uptake, intrahepatic cholestasis, extrahepatic cholestasis. In both models, ku showed significant difference between low uptake positive and negative groups and ke showed significant difference between extrahepatic cholestasis positive and negative groups. Only mean uptake time (Vn/ku) by 3 parameter model showed significant difference between intrahepatic cholestasis positive and negative groups, although the other 2 parameters (ku, ke) were insensitive to intrahepatic cholestasis in either model. Thus, the 3 parameter model was superior to the 2 parameter model because of its sensitivity to intrahepatic cholestasis and ability to differentiate extrahepatic and intrahepatic cholestasis as the difference of parameter values. Based on this 3 parameter model, parametric images were generated by calculating parameter value of each pixel using the DILS method. The DILS method could determine parameters by simple calculation, and hence was very powerful in processing parametric images, which processing otherwise required immense calculation.
PracticeClinical medicine
KeywordsHepatobiliary scintigraphy, Hepatogram analysis, Direct integral linear least square regression method.

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