| Japanese |
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| Title | ジピリダモール負荷心筋シンチグラフィにおけるびまん性washout低下の意義 |
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| Subtitle | ≪原著≫ |
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| Authors | 米澤嘉啓*, 浜重直久**, 土居義典*, 小田原弘明*, 高田淳*, 山田光俊*, 小澤利男*, 赤木直樹***, 前田知穂***, 吉田祥二**** |
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| Authors(kana) | |
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| Organization | *高知医科大学老年病科, **近森病院循環器科, ***高知医科大学放射線科, ****兵庫県立成人病センター放射線科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 4 |
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| Page | 355-360 |
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| Year/Month | 1991/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」ジピリダモール負荷心筋シンチグラフィと冠動脈造影を行った382例の患者で, びまん性washout低下(Diffuse Slow Washout: DSW)の臨床的意義を検討した. DSWは, 欠損像陽性の285例中69例(24%), 欠損像陰性の97例中5例(5%)に認めた. DSWと欠損像には有意の関連がみられた(p<0.01). 冠動脈造影では, DSW陽性群の84%が多枝病変, 12%が1枝病変であったのに対し, DSW陰性群ではそれぞれ, 28%, 50%であった. 平均29か月の観察では, 欠損像陽性でDSWを認めた69例中41%に初期血行再建術が行われ, 12%の心臓死, 7%の非致死的心合併症がみられたが, DSWを認めない216例では初期血行再建術は11%, 心臓死は7%, 非致死的心合併症は5%と比較的低率であった. 欠損像陰性例では, DSWの有無によらず予後良好であった. 欠損像陽性例では, DSWは重症虚血を示唆するが, 欠損像陰性例では, DSWは虚血と関連していないと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | washout rate, dipyridamole, thallium-201 myocardial perfusion scintigraphy, ischemic heart disease, prognosis. |
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| English |
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| Title | Significance of Diffuse Slow Washout in Dipyridamole Loading Thallium-201 Myocardial Perfusion Scintigraphy |
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| Subtitle | - Original Articles - |
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| Authors | Yoshihiro YONEZAWA*, Naohisa HAMASHIGE**, Yoshinori DOI*, Toshio OZAWA*, Hiroaki ODAWARA*, Jun TAKATA*, Mitsutoshi YAMADA*, Naoki AKAGI***, Tomoho MAEDA***, Syoji YOSHIDA**** |
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| Authors(kana) | |
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| Organization | *Section of Cardiology, Department of Internal Medicine and Geriatrics, Kochi Medical School, **Department of Cardiology, Chikamori Hospital, ***Department of Radiology, Kochi Medical School, ****Department of Radiology, Hyogo Seijinbyo Center |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 4 |
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| Page | 355-360 |
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| Year/Month | 1991/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To assess the significance of diffuse slow washout (DSW) in dipyridamole loading thallium-201 myocardial perfusion scintigraphy, 382 patients were studied. DSW were observed in 69 (24%) of 285 patients with perfusion defects, 5 (5%) of 97 patients without perfusion defects. There was significant relation between DSW and perfusion defects (p<0.01). Coronary angiography showed multivessel disease in 84%, single vessel disease in 12% of patients with DSW and multivessel disease in 28%, single vessel disease in 50% of patients without DSW. During a mean follow up period of 29 months, initial CABG or PTCA were done in 41%, cardiac death occurred in 12%, nonfatal cardiac events occurred in 7% of patients with DSW and perfusion defects. In patients without DSW, initial CABG or PTCA were done in 11%, cardiac death occurred in 7%, nonfatal cardiac events occurred in 5%. Patients without perfusion defects had good prognosis regardless of the presence or absence of DSW. In conclusion, DSW indicates serious cardiac ischemia in patients with perfusion defects. DSW does not indicate cardiac ischemia in patients without perfusion defects. |
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| Practice | Clinical medicine |
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| Keywords | washout rate, dipyridamole, thallium-201 myocardial perfusion scintigraphy, ischemic heart disease, prognosis. |
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