| Japanese |
|---|
| Title | Flosequinanの肺血管拡張作用 - デジタル肺血流像による評価 - |
|---|
| Subtitle | 原著 |
|---|
| Authors | 田中健*, 相澤忠範*, 加藤和三*, 岡本淳* |
|---|
| Authors(kana) | |
|---|
| Organization | *心臓血管研究所 |
|---|
| Journal | 核医学 |
|---|
| Volume | 28 |
|---|
| Number | 3 |
|---|
| Page | 241-246 |
|---|
| Year/Month | 1991/3 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」血管拡張剤であるflosequinan (F) の肺血管拡張作用をTc-99m MAA肺血流像と二回注入法を用いて慢性心不全17例において検討した. 肺血流像はF100mgを服用前と服用2時間後に撮像した. 右肺横隔膜頂上部と肺尖部との間にプロフィールカーブを求め服用前後でカーブが囲む面積が同じになるように補正し, 高さで2等分し上肺野と下肺野とした. 肺内血流分布の定量的評価はこの上下の面積比によって行った (U / L). 下肺野の肺血流量の増加率として下肺野に対応する面積の増加率 (ΔL%) を求めた. 17例いずれにおいてもU / Lの改善 (0.82±0.22→0.63±0.24 p < 0.001, ΔL : 9.6±6.4%) を認めFによる下肺野肺血流量の増加が示された. 特に3例では上肺全域に認められた高肺血流域の消失が認められ, 下肺野肺血流量の増加率は最低でも20%と推定された. Fは肺血管を拡張する作用があり, この効果は下肺野で強い事が示された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | vasodilator, Tc-99m-MAA pulmonary perfusion images, congestive heart failure. |
|---|
| English |
|---|
| Title | Direct Vasodilatation Effect of Flosequinan on Pulmonary Vascular Bed. Estimation by Digital Perfusion Images |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Takeshi TANAKA, Tadanori AIZAWA, Kazuzo KATOU, Kiyoshi OKAMOTO |
|---|
| Authors(kana) | |
|---|
| Organization | The Cardiovascular Institute |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 28 |
|---|
| Number | 3 |
|---|
| Page | 241-246 |
|---|
| Year/Month | 1991/3 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] Flosequinan (F) is a potent vasodilator and produces hemodynamic improvement when given to patients (pts) with congestive heart failure (CHF) but little is known about its direct effect on the regional pulmonary vascular bed. Pulmonary perfusion in erect position is known to vary according to the changes of pulmonary hemodynamics. To determine the acute effect of F on pulmonary perfusion 17 pts with CHF (NYHA 2-3, ejection fraction 30 +- 10%) underwent Tc-99m-MAA pulmonary perfusion images in erect position before and 2 hours after administration of 100mg dose of F. Pulmonary perfusion were assessed by ratio of upper to lower zone counts in the images (U / L). Increase rate of the lower zone area was assessed by ΔL / L (4Δ, %). ΔL was thought to correspond to increase rate of pulmonary perfusion in the lower lung zone. In all pts significant decrease in U / L (0.82 +- 0.22→0.63 +- 0.24 p < 0.001) was noted. ΔL was 9.6 +- 6.4%. Increase in perfusion to the lower lung zone indicated localized vasodilatation effect of F. In 11 pts with basal hyperperfusion area U / L improved from 0.63 +- 0.08 to 0.49 +- 0.07 and mean ΔL was 9.6 +- 6.4%. This showed increase of pulmonary perfusion in the lower zone. In 3 pts of 6 pts without basal hyperperfusion area pulmonary perfusion in the lower zone markedly increased and hyperperfusion area noted in the upper zone disappeared after administration of F. ΔL was 21, 32 and 29% respectively. This corresponded to the dilation of pulmonary vascular bed in the basal zone. It was suggested that F improved vasoconstriction in the basal zone. In remaining 3 pts. U / L improved from 1.19 +- 0.13 to 1.08 +- 0.19 and ΔL was 1, 5 and 8.5% respectively. Slight increase of pulmonary perfusion in the lower lung zone might show the organic change of the pulmonary vascular bed in the lower lung zone. It was concluded that F has direct heterogeneous vasodilatation effect on pulmonary vascular bed. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | vasodilator, Tc-99m-MAA pulmonary perfusion images, congestive heart failure. |
|---|