| Japanese |
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| Title | 健常者における大脳小脳間の機能的関連 |
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| Subtitle | 原著 |
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| Authors | 羽生春夫*, 新井久之*, 羽田野展由*, 阿部晋衛*, 勝沼英宇* |
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| Authors(kana) | |
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| Organization | *東京医科大学老年科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 3 |
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| Page | 221-227 |
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| Year/Month | 1991/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」健常成人21例の安静時における脳血流量の左右差を評価し, 大脳小脳間の関連について検討した. 脳血流測定には123I-IMPによるSPECTを用い, 左右差指数AI = R - L/R + L/200 (%) を指標とした. AIによる小脳半球と大脳半球局所における相関を求めると, 後頭葉皮質を除いた各領域で負の相関係数が得られた. このうち前頭葉皮質 (上部 : r = -0.58, p < 0.01, 中部 : r = -0.55, p < 0.02, 下部 : r = -0.49, p < 0.05) では有意な負の相関が認められ, 大脳半球平均 (r = -0.52, p < 0.02) においても有意であった. 本成績から, 健常者の生理的状態においても大脳小脳間には主に皮質橋小脳路を介した機能的関連の存在することが示唆され, 特に前頭葉皮質の対側小脳半球に及ぼす影響が大きいと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Cerebrum, Cerebellum, Corticopontocerebellar tract, SPECT, IMP. |
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| English |
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| Title | Functional Relationship between the Cerebrum and Cerebellum in Normal Subjects |
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| Subtitle | Original Articles |
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| Authors | Haruo HANYU, Hisayuki ARAI, Nobuyoshi HATANO, Shinei ABE, Hideyo KATSUNUMA |
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| Authors(kana) | |
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| Organization | Department of Geriatric Medicine, Tokyo Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 3 |
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| Page | 221-227 |
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| Year/Month | 1991/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To determine whether a functional relationship between the cerebrum and cerebellum exists in normal subjects, the correlation between asymmetry in cerebral blood flow and asymmetry in cerebellar blood flow was investigated. Twenty-one healthy right-handed subjects were studied using SPECT with N-isopropyl-p-(123I)iodoamphetamine while in a resting state. The asymmetry index (AI) for both the cerebral and cerebellar hemisphere was calculated as follows. AI = R - L/R + L/200 (%) (R : right side, L : left side). A negative correlation was found between AI in the cerebellum and AI in cerebrum. Especially, AI in cerebellar hemisphere was significantly correlated with AIs in the upper frontal cortex (r = -0.58, p < 0.01), middle frontal cortex (r = -0.55, P < 0.02), lower frontal cortex (r = -0.49, p < 0.05), and mean cerebral hemisphere (r = -0.52, p < 0.02). These results suggest the existence of a functional relationship between the cerebral hemisphere and the contralateral cerebellar hemisphere in the resting state of normal subjects. We strongly suspect that the frontal cortex exert an influence on the function in the contralateral cerebellum, probably due to a transneuronal mechanism, mainly through the corticopontocerebellar pathway. |
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| Practice | Clinical medicine |
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| Keywords | Cerebrum, Cerebellum, Corticopontocerebellar tract, SPECT, IMP. |
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