| Japanese |
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| Title | びまん性肺疾患における123I-IMP肺クリアランスの検討 |
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| Subtitle | ≪短報≫ |
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| Authors | 高橋恒男*, 加藤邦彦*, 柳澤融*, 米谷則美**, 田村昌士** |
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| Authors(kana) | |
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| Organization | *岩手医科大学放射線科, **第三内科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 2 |
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| Page | 191-195 |
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| Year/Month | 1991/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-IMPは初回肺循環で肺内へ高率に取り込まれ, 徐々に放出されるが, 肺病変によりその代謝過程が変化すると考えられる. 今回健康な非喫煙若年男性5例と各種びまん性肺疾患15例を対象に123I-IMP肺シンチグラフィを行い, 1 frame/minで60分間データ収集し, 両肺野全体を関心領域として, その時間放射能曲線をC(t)-A1e-k1t+A2e-k2tの2 compartment modelにて解析した. その結果, 疾患例では健康例に比し有意に123I-IMPの肺からの洗い出しの遅延をみ, また洗い出し率K2は肺病変の活動性の指標67Ga computer activity index (Ga-CAI)と負の相関(r=-0.627, p<0.01)を, 肺機能のうち, %DLcoとは正の相関(r=0.725, p<0.01)を認めた. 以上より, 123I-IMP肺シンチグラフィにおける肺洗い出し曲線の検討はびまん性肺疾患の病変の活動性の評価に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, diffuse lung diseases, 67Ga lung activity. |
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| English |
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| Title | 123I-IMP Clearance of the Lung with Diffuse Lung Disease |
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| Subtitle | - Short Communication - |
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| Authors | Tsuneo TAKAHASHI*, Kunihiko KATO*, Toru YANAGISAWA*, Norimi MAIYA**, Masashi TAMURA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Third Department of Internal Medicine, Iwate Medical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 2 |
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| Page | 191-195 |
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| Year/Month | 1991/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] N-isopropyl-I-123-p-iodoamphetamine (123I-IMP) is taken up by the capillary endothelial cells during the first pulmonary pass and is released from the lung. To evaluate the effect of the 123I-IMP retention on diffuse lung disease, we studied prolonged 123I-IMP clearance from lung in 5 non-smoking control volunteers and 15 patients with various diffuse lung diseases. The time-activity curve for 60 min after the injection of 111 MBq of 123I-IMP was described as follows: C(t)=A1e-k1t + A2e-k1t (A1, A2: intercepts; K1, K2: slopes of the exponential components). 123I-IMP clearance was delayed in the patient group and K2 was significantly lower. There was a significant correlation between K2 and Ga-computer activity index on the 67Ga scintigraphy in the patient group. K2 was also correlated with %DLco on the pulmonary function test. Our study suggests that the delayed clearance and retention of 123I-IMP in the diseased lung are influenced by the pathological activity in the lung lesion. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, diffuse lung diseases, 67Ga lung activity. |
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