Japanese |
Title | 甲状腺シンチグラフィにて陽性結節を認めた症例の核医学的考察 - 病理組織像と対比して - |
Subtitle | ≪原著≫ |
Authors | 津田隆俊*, 久保田昌宏*, 若林淳一**, 平田健一郎***, 浅石和明****, 森田和夫* |
Authors(kana) | |
Organization | *札幌医科大学放射線医学講座, **付属病院病理部, ***機器診断部, ****第一外科学講座 |
Journal | 核医学 |
Volume | 28 |
Number | 2 |
Page | 163-176 |
Year/Month | 1991/2 |
Article | 原著 |
Publisher | 日本核医学会 |
Abstract | 「要旨」われわれは, 触診などにて結節性甲状腺腫と考えられ, 99mTcO4-または123I甲状腺シンチグラムで, 腫瘍に一致して陽性結節像が得られ, 良性甲状腺腫瘍と考えられた34症例で核医学像と病理組織像とを対比した. 対象34例中30例は手術で組織診がえられ, 4例は吸引細胞診でその病理像が確定された. 34例のうち非中毒性の結節性甲状腺腫は30例であったが, 悪性結節は1例(3.3%)で29例(96.7%)は良性結節であった. 甲状腺シンチグラム上, 陽性結節像を呈したなかに4例の慢性甲状腺炎があったが, 超音波検査ではいずれも甲状腺に結節を認めず, そのうち2例は手術で瀰漫性甲状腺腫であることが確認され, 2例は吸引細胞診で慢性甲状腺炎と診断された. 99mTcO4-スキャンと123Iスキャンの両方の検査が施行された6症例8結節のうち, 7結節の集積のパターンは同一であった, 1例の集積パターンには差異が認められたが組織像には悪性の所見はなかった. 結節性甲状腺腫30例(32病巣)の検討で, 201Tlの結節性病変部への集積の程度は, 良悪の性質より, 腫瘍のviability, 腫瘍のvolumeまた嚢胞性変化を反映していた. 好酸性細胞腫2例を経験したが, 1例は陽性結節で組織学的に細胞異型や被膜浸潤のない濾胞腺腫と診断された. 他の1例は左葉下極に陽性結節を認め右葉上極に陰性結節を認めた症例であった. 組織学的検査で, 左葉の結節は嚢胞変性をともなう濾胞腺腫, 右葉のそれは被膜浸潤をともなう好酸性細胞腫と診断された. 以上の検討から, 甲状腺腫には機能的に均一でなく異質の部分が混在していることが強く示唆された. 99mTcO4-陽性結節が良性の濾胞腺腫である正診率が高く, 悪性甲状腺腫瘍を診断する目的で行われる放射性ヨウ素による甲状腺シンチグラフィの臨床的意義は小さいと思われる. |
Practice | 臨床医学:一般 |
Keywords | Hot nodule, 99mTcO4- thyroidscintigraphy, 123I scintigraphy, Histopathology. |
English |
Title | Clinical Evaluation of the Hot Nodule on 99mTcO4- and 123I Thyroid Scintigraphy : Correlation of Scan Appearance and Histopathology |
Subtitle | - Original Articles - |
Authors | Takatoshi TSUDA*, Masahiro KUBOTA*, Jun-ichi WAKABAYASHI**, Ken-ichiro HIRATA***, Kazuaki ASAISHI****, Kazuo MORITA* |
Authors(kana) | |
Organization | *Department of Radiology, Sapporo Medical College, **Division of Clinical Pathology, ***Division of Ultrasound and Medical Electronics, Sapporo Medical College Hospital, ****First Department of Surgery, Sapporo Medical College |
Journal | The Japanese Journal of nuclear medicine |
Volume | 28 |
Number | 2 |
Page | 163-176 |
Year/Month | 1991/2 |
Article | Original article |
Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
Abstract | [Summary] Histopathology and scan findings of hot nodule on 99mTcO4- and/or 123I were correlated in 34 patients with thyroid nodules. In a series of 30 hot nodular lesions, 29 were either adenomas or benign nodules ; however, one was proved follicular carcinomas histopsthologically. And four patients were chronic thyroiditis without nodular lesions in the thyroid lobes, which were diagnosed pathologically and clinically. In 6 patients with palpable thyroid nodules, thyroid scans performed with both 99mTcO4- and 123I were compared. A discrepancy of the two types of scan existed in only one case. Subsequent surgery revealed no malignancy in this patient. From the results of 201Tl imaging of the thyroid gland in 30 patients with cold or hot nodules on either 99mTcO4- or 123I thyroid scanning, we found no distinct difference between the degrees of 201Tl malignant and nonmalignant tumors. It appears that 201Tl accumulation demonstrates only tumor volume and tumor cell viability in these subjects. From these results, it is confirmed that the functional heterogenieties exist in thyroid adenoma tissues as well as in thyroid cancerous tissues. Therefore, the development of the reliable techniques used to distinguish a benign from malignant lesion is indispensable. |
Practice | Clinical medicine |
Keywords | Hot nodule, 99mTcO4- thyroidscintigraphy, 123I scintigraphy, Histopathology. |