| Japanese |
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| Title | 99mTc-SQ30217による心筋血流イメージング : 3検出器型SPECTの応用 |
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| Subtitle | ≪原著≫ |
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| Authors | 中嶋憲一*, 滝淳一*, 分校久志*, 村守朗*, 松成一朗*, 小西堅正**, 久田欣一*, 市原隆*** |
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| Organization | *金沢大学医学部核医学科, **第二内科, ***(株)東芝那須工場 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 2 |
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| Page | 127-133 |
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| Year/Month | 1991/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」新しい心筋血流用放射性医薬品である99mTc-SQ30217を用いて, 早期の心筋, 肺, 肝臓の経時的変化をSPECTにより検討した. データ収集は高感度収集が可能な3角型SPECTを用い連続反復収集法による動態収集を行った. 心筋の摂取率は注射後早期に最大に達し, 以後早いクリアランスで消失した. 2指数関数で近似すると梗塞のない心筋での第1相の半減期は2.8分(k1値0.25±0.12/分), 第2相の半減期は57分(k2値0.012±0.011/分)であった. 肺からのクリアランスは心筋よりも早く, 一方, 肝の集積は早期に増加し10〜15分で最大に達した. 再編集したSPECT画像について検討すると, 静注10分以内の収集時間3分のSPECT画像は, 静注10分以降の画像よりも, 画質が良好で肝の集積による心筋の下壁中隔への影響も少なかった. したがってこの薬剤には早いSPECTデータ収集が望ましいと考えられた. 99mTc-SQ30217は心筋血流イメージング用剤として有望な薬剤であることが結論された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-SQ30217, myocardial scintigraphy, three-headed SPECT, continuous repetitive acquisition. |
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| English |
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| Title | Myocardial Perfusion Imaging with 99mTc-SQ30217 : Application of Three-headed SPECT System |
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| Subtitle | - Original Articles - |
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| Authors | Kenichi NAKAJIMA*, Junichi TAKI*, Hisashi BUNKO*, Akira MURAMORI*, Ichiro MATUNARI*, Kensho KONISHI**, Kinichi HISADA*, Takashi ICHIHARA*** |
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| Authors(kana) | |
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| Organization | *Department Of Nuclear Medicine, **Second Department Of Internal Medicine, Kanazawa University, ***Toshiba, Nasu Works |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 2 |
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| Page | 127-133 |
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| Year/Month | 1991/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The early dynamic change of a new myocardial imaging sgent, 99mTc-SQ30217, was investigated in SPECT study. A three-headed high sensitivity SPECT system was employed to evaluate the serial changes of accumulation pattern in the heart, lung and liver using a "continuous repetitive acquisition" mode. The myocardial activity reached a peak rapidly and decreased with rapid clearance rate. The analysis of myocardial clearance curve showed a T1/2 of 2.8 minutes(k1=0.25 +- 0.12/min)in the rapid phase, and a T1/2 of 57 minutes(k2=0.012 +- 0.011/min)in the slow phase. The tracer clearance in the lung was more rapid, while the hepatic uptake reached a peak approximately 10 to 15 minutes after injection. When the serial SPECT images were reviewed, the early 3-minute acquisition within 10 minutes after injection showed better image quality than the images obtained after 10 minutes. The hepatic activity did not obscure the inferoseptal wall in the earlier images, but did in the images 10 minutes after injection. Thus, quick SPECT data acquisition seemed to be desirable for this agent. We concluded that 99mTc-SQ30217 was a promising radiopharmaceutical for myocardial perfusion imaging. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-SQ30217, myocardial scintigraphy, three-headed SPECT, continuous repetitive acquisition. |
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