| Japanese |
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| Title | ヒト前頭葉における11C-N-methylspiperoneの結合能の加齢による変化 |
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| Subtitle | 原著 |
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| Authors | 米澤久司*,**, 伊豫雅臣*, 伊藤高司***, 福田寛*, 山崎統四朗*, 井上修*, 須原哲也*, 篠遠仁*, 西尾正人*, 東儀英夫**, 舘野之男* |
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| Authors(kana) | |
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| Organization | *放射線医学総合研究所臨床研究部, **岩手医科大学神経内科学講座, ***日本医科大学数学科教室 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 1 |
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| Page | 63-69 |
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| Year/Month | 1991/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Positron emission tomography (PET) を用いて前頭皮質における11C-N-methylspiperone (NMSP) とserotonin S2受容体との結合能の加齢にともなう変化について, 22歳から72歳までの健常ボランティア11例について検討した. 前頭皮質での11C-NMSPの取り込みは静注後5〜15分でピークに達し徐々に減少し, 小脳では約10分でピークに達したのち速やかな減少を認めた. 解析には3-コンパートメントモデルを用いた. NMSPと特異的結合部位をもたない小脳を入力関数として, 結合速度定数k3・解離速度定数k4を求め, その比を結合能 (k3 / k4) として定量評価した. 結合能は加齢にともない著明な減少を認めた. この減少は主に結合速度定数k3の低下によるものであった. 結合能は親和定数Kdと最大結合数Bmaxを用いてBmax / Kdで表わされるが, 加齢にともなう結合能の低下は前頭皮質におけるserotonin S2受容体のBmaxの減少によるものと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | PET,11C-NMSP, Serotonin S2 Receptor, Aging, Frontal cortex. |
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| English |
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| Title | Effect of Aging on in vivo Binding of 11C-N-methylspierone in Living Human Frontal Cortex |
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| Subtitle | Original Articles |
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| Authors | Hisashi YONEZAWA*)**, Masaomi IYO*, Takashi ITOH***, Hiroshi FUKUDA*, Toshiro YAMASAKI*, Osamu INOUE*, Tetsuya SUHARA*, Hitoshi SHINOTOH*, Masato NISHIO*, Hideo TOHGI**, Yukio TATENO* |
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| Authors(kana) | |
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| Organization | *Division of Clinical Research, National Institute of Radiological Sciences, **Department of Nueurology, School of Medicine, Iwate Medical University, ***Department of Mathematics, Nippon Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 1 |
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| Page | 63-69 |
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| Year/Month | 1991/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Reduced in vivo binding of 11C-N-methyl-spiperone (NMSP) with age in the living human frontal cortex was demonstrated, with positron emission tomography (PET). Eleven normal male volunteers (22 to 72 years old) were assessed. The uptake of 11C-NMSP in the frontal cortex peaked 7-15 min after intravenous injection, and then gradually decreased until the end of this study. On the other hand in the cerebellum, the uptake of 11C-NMSP peaked 10 min and rapidly declined. We analyzed the data using a three compartment model and determined rate constants k3 and k4. And the binding potential of receptors was estimated as the ratio of k3 (association rate constant) to k4 (dissociation rate constant) value. The k3 and k4 values were calculated from non-linear regression, given by the set of parameter values that minimized the deviation between the measured kinetics and model prediction. As an input function, we used the radioactivity in the cerebellum. A significant reduction in BP with age was observed. Though both k3 and k4 values were decreased with age, this decrease of BP was found to be mainly due to the reduced k3 values. These results indicated that numbers of binding sites (Bmax) of serotonin S2 receptors in frontal cortex might be decreased with age. |
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| Practice | Clinical medicine |
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| Keywords | PET,11C-NMSP, Serotonin S2 Receptor, Aging, Frontal cortex. |
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