| Japanese |
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| Title | 末端肥大症における心筋血流および心機能変化の検討 |
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| Subtitle | 原著 |
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| Authors | 河村康明*, 山崎純一*, 奥住一雄*, 武藤敏徳*, 森下健*, 宮地幸隆*, 入江實*, 井上和子** |
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| Organization | *東邦大学医学部内科学第一講座, **医療短大 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 1 |
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| Page | 19-25 |
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| Year/Month | 1991/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」末端肥大症16名の心筋血流および心機能の変化をTl-201心筋シンチグラフィ, Tc-99mHSA心シンチグラフィによって検討した. 運動負荷Tl-201試験では固定性欠損10例 (62.5%), 心筋肥大9例 (56.3%), 心拡大4例 (25.0%) などの多様な心筋変化が認められた. また, 心機能では心拍出量6.4±1.7L/min, 左室駆出率 (LVEF) 47.8±17.1%, 右室駆出率 (RVEF) 37.3±14.9%と高心拍出であり左室駆出率はほぼ正常を示した. 以上のように, 末端肥大症の心筋血流, 心機能の変化より, 成長ホルモンの直接・間接作用による二次性心筋症の可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Acromegaly, Tl-201, Cardiomyopathy, Cardiac function. |
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| English |
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| Title | Evaluation of Myocardial Blood Flow and Cardiac Functional Change in Acromegaly |
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| Subtitle | Original Articles |
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| Authors | Yasuaki KAWAMURA*, Junichi YAMAZAKI*, Ichio OKUZUMI*, Toshinori MUTO*, Takeshi MORISHITA*, Yukitaka MIYACHI*, Minoru IRIE*, Kazuko INOUE** |
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| Authors(kana) | |
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| Organization | *The First Department of Internal Medicine, Toho University School of Medicine, **Toho University College of Health Professions |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 1 |
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| Page | 19-25 |
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| Year/Month | 1991/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We studied 201Tl myocardial scintigraphy and 99mTc-HSA gated blood pool scan to evaluate the influence of growth hormone on myocardial blood flow and hemodynamics in 16 patients with acromegalies. Contraction properties were almost within normal limit, but cardiac output was in high output state, because left ventricular ejection fraction (LVEF), right ventricular ejection fraction (RVEF) and cardiac output were 47.8 +- 17.1%, 37.3 +- 14.9%, and 6.4 +- 1.7L/min, respectively. Otherwise, 201Tl myocardial images revealed 62.5% no redistributed hypoperfusion, 18.8% redistributed hypoperfusion, 56.3% myocardial hypertrophy and 25.0% left ventricular enlargement. These data suggested the high incidence of acromegalic cardiomyopathy due to primary or secondary growth hormone effect. |
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| Practice | Clinical medicine |
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| Keywords | Acromegaly, Tl-201, Cardiomyopathy, Cardiac function. |
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