| Japanese |
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| Title | 蛋白漏出性胃腸症における111In-トランスフェリン腹部イメージングの有用性 |
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| Subtitle | 原著 |
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| Authors | 油野民雄*, 横山邦彦*, 絹谷清剛*, 秀毛範至*, 高山輝彦*, 利波紀久*, 久田欣一*, 増永高晴**, 竹田康男**, 竹田亮祐** |
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| Authors(kana) | |
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| Organization | *金沢大学医学部核医学教室, **第二内科学教室 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 1 |
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| Page | 11-17 |
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| Year/Month | 1991/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」α1-アンチトリプシン・クリアランス値または胃液中の蛋白含有量より, 消化管からの蛋白漏出陽性と診断された17症例を対象として, 111In-トランスフェリン腹部イメージングの臨床的有用性を検討した. α1-アンチトリプシン検査で13ml/day以下の数値 (正常値) を呈した7例中5例, および13ml/day以上かつ20ml/day以下の数値を呈した3例全例では, 蛋白漏出を示す明瞭な放射能が認められなかったものの, 20ml/day以上の数値を呈した7例全例, および胃液中の蛋白含有量の高値より消化管からの蛋白漏出陽性と診断された胃疾患2例の計9例では, 蛋白漏出の存在を示す明瞭な放射能集積が認められるとともに, 漏出部位もおおよそ推定された. 以上より111In-トランスフェリン腹部イメージングは, 消化管からの蛋白漏出の証明手段 (特にα1-アンチトリプシン検査で必ずしも異常値を示さないことが多い胃疾患時), 漏出部位の推定手段として有用と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Protein losing gastroenteropathy, In-111 transferrin, Radionuclide abdominal imaging. |
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| English |
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| Title | The Diagnostic Value of In-111 Transferrin Imaging in Protein-Losing Gastroenteropathy |
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| Subtitle | Original Articles |
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| Authors | Tamio ABURANO*, Kunihiko YOKOYAMA*, Seigo KINUYA*, Noriyuki SHUKE*, Teruhiko TAKAYAMA*, Norihisa TONAMI*, Kinichi HISADA*, Takaharu MASUNAGA**, Yasuo TAKEDA**, Ryoyu TAKEDA** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Second Department of Internal Medicine, School of Medicine, Kanazawa University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 1 |
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| Page | 11-17 |
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| Year/Month | 1991/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The diagnostic value of In-111 transferrin abdominal imaging was studied in 17 patients with clinical suspicion of protein-losing gastroenteropathy, compared to that of alpha-1-antitrypsin fecal clearance test. The presence or absence of gastrointestinal protein-loss was finally decided based on the result of alpha-1-antitrypsin fecal clearance test (normal range, less than 13ml/day) or of protein content measurement on the gastric juice (normal range, less than 71mg/dl). In-111 transferrin was labeled in vitro. After intravenous administration, serial anterior abdominal images were obtained. All seven patients with a value equal to or more than 20ml/day on the alpha-1-antitrypsin clearance test and two out of ten patients with a value less than 20ml/day showed definite intestinal activity demonstrating protein-loss, and the loss-site was estimated by observing the movement of radiotracer within the bowel lumen. The patients with severe protein-loss showed the intestinal activity on the early image. In the patients with milder protein-loss, on the other hand, the activity was noted on the later image. All two patients with positive In-111 transferrin imaging and negative alpha-1-antitrypsin test were associated with protein-losing gastropathy, where a value of alpha-1-antitrypsin clearance was not increased because of denatured alpha-1-antitrypsin by acidic gastric juice and pepsin. These results suggest that In-111 transferrin abdominal imaging can be more useful for the diagnosis of protein-losing gastroenteropathy, because of its capabilities to evaluate the patients with gastropathy as well as to estimate the loss-site. |
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| Practice | Clinical medicine |
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| Keywords | Protein losing gastroenteropathy, In-111 transferrin, Radionuclide abdominal imaging. |
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