| Japanese |
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| Title | Rutland法による肝内シャントの測定 |
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| Subtitle | 原著 |
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| Authors | 権重禄*, 中川毅**, 多上智康**, 前田寿登****, 北野外紀雄***, 佐久間肇**, 中村和義** |
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| Authors(kana) | |
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| Organization | *中国医科大学核医学科, **三重大学医学部放射線科, ***三重大学医学部附属病院中央放射線部, ****藤田学園保健衛生大学衛生学部診療放射線技術科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 1 |
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| Page | 1-10 |
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| Year/Month | 1991/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-PMT肝胆道イメージングのデータをRutland法により解析し, uptake constantと血中バックグラウンドの割合から肝内シャント率を測定した. さらに血中クリアランス法で求めた有効肝血流量を用いて, シャント量, 全肝血流量を求めた. 正常例15例のシャント率, シャント量, 全肝血流量の平均値と標準偏差は, それぞれ, 18.4±5.4%, 137.8±49ml/min, 753±83.2ml/minであった. 慢性肝炎8例では, それぞれ, 35.2±2.6%, 276±55.4ml/min, 794.1±119.4ml/minであり, 肝硬変例12例では, それぞれ, 51.4±12.6%, 353.9±141.3ml/min, 685.6±174.8ml/minであって, シャント率, シャント量ともに慢性肝炎, 肝硬変群では, 正常例に比し, 0.1%の危険率で有意に増加し, 有効肝血流量は, 0.1%の危険率で有意に低下し, 全肝血流量には, 有意の変動はみられなかった. シャント率と有効肝血流量との間には相関係数-0.842の良好な逆相関が認められた. 本法は, 疾患の鑑別診断, 重症度の判定, 種々の病態生理の検討に有用と思われる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Hepatic blood flow, Uptake constant, Intrahepatic shunt, 99mTc-PMT, Hepatobiliary scintigraphy. |
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| English |
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| Title | Measurement of Intrahepatic Shunt Using Rutland Method |
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| Subtitle | Original Articles |
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| Authors | Jyuroku GON*, Tsuyoshi NAKAGAWA**, Tomoyasu TAGAMI**, Hisato MAEDA****, Tokio KITANO***, Hajime SAKUMA**, Kazuyoshi NAKAMURA** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, China Medical University, **Department of Radiology, Mie University School of Medicine, ***Radiological Center, Mie University Hospital, ****School of Radiological Technology, Fujita Gakuen Health University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 1 |
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| Page | 1-10 |
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| Year/Month | 1991/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Intrahepatic shunt ratio was calculated from the fraction of the uptake constant and the blood background, analyzing the data of 99mTc-(Sn)-N-pyridoxyl-5-methyltryptophan (99mTc-PMT) hepatobiliary imaging by Rutland method. Shunt flow and total hepatic blood flow (THBF) were also calculated from the values for the effective hepatic blood flow (EHBF) estimated from the blood clearance technique. In 15 cases of normal volunteer, the average of the shunt ratio, shunt flow, and THBF were 18.4 +- 5.4 (S.D.)%, 137.8 +- 49ml/min, and 753 +- 83.2ml/min, respectively. In 8 cases of chronic hepatitis, the values were 35.2 +- 2.6%, 276 +- 55.4ml/min, and 794.1 +- 119.4ml/min, respectively. In 12 cases of liver cirrhosis, the values were 51.4 +- 12.6%, 353.9 +- 141.3ml/min, and 685.6 +- 174.8ml/min, respectively. In cases of chronic hepatitis and liver cirrhosis, in comparison with normal cases, the values for the shunt ratio and shunt flow were significantly increased (p < 0.001) and those for EHBF were significantly decreased (p < 0.001), but those for THBF were not significantly altered. There was a significant inverse correlation between the shunt ratio and EHBF (r = -0.842) in all 35 cases. This method is considered to be useful for differential diagnosis, estimation of the grade of the diseases, and evaluation of pathophysiology of various diffuse liver diseases. |
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| Practice | Clinical medicine |
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| Keywords | Hepatic blood flow, Uptake constant, Intrahepatic shunt, 99mTc-PMT, Hepatobiliary scintigraphy. |
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