| Japanese |
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| Title | アルツハイマー型老年痴呆における局所脳循環の左右差について - 123I-IMP SPECTによる検討 - |
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| Subtitle | 原著 |
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| Authors | 新井久之*, 羽生春夫*, 小林康孝*, 羽田野展由*, 勝沼英宇*, 鈴木孝成**, 網野三郎** |
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| Authors(kana) | |
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| Organization | *東京医科大学老年科, **放射線科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 12 |
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| Page | 1401-1410 |
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| Year/Month | 1990/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」アルツハイマー型老年痴呆 (SDAT) 患者22例および健常高齢者18例に123I-IMP SPECTを実施し, Asymmetry Index (AI) を算出し脳血流の左右差に関して検討を加えた. 左右差を認めた症例の部位別頻度はParietal (68.2%), 次いでMiddle Frontal (63.6%) にて高く, OccipitalやBasal Gangliaでは認められなかった. 左右差の大きさはParietal (|AI| = 5.77), 次いでTemporal (5.31) にて大きく, Occipital, Cerebellumでは有意な左右差は見られなかった. 大脳半球局所のAIと小脳半球でのAIは全体的に負の相関を呈し, Lower Frontalでは相関係数r = -0.76と特に強い負の相関が見いだされた. また, 臨床症状と左右差の対比を見ると, Parietalで右側優位な血流の低下症例は視空間認知障害が強く, 左側優位な低下症例では言語障害が強く認められた. 123I-IMP SPECTは, SDATにおける脳血流の左右差を評価するのに有用と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl-p-[123I]iodoamphetamine, single photon emission computed tomography, senile dementia of Alzheimer type, asymmetry, crossed cerebellar diaschisis. |
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| English |
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| Title | Asymmetry of Cerebral Blood Flow in Patients with Senile Dementia of Alzheimer Type by SPECT Using I-123 IMP |
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| Subtitle | Original Articles |
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| Authors | Hisayuki ARAI*, Haruo HANYU*, Yasutaka KOBAYASHI*, Nobuyoshi HATANO*, Hideyo KATSUNUMA*, Takanari SUZUKI**, Saburo AMINO** |
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| Authors(kana) | |
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| Organization | *Departments of Geriatric Medicine and **Radiology, Tokyo Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 12 |
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| Page | 1401-1410 |
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| Year/Month | 1990/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Regional cerebral blood flow (rCBF) was determined by single photon emission CT (SPECT) with N-isopropyl-p-[123I]iodoamphetamine in 22 patients with clinically diagnosed senile dementia of Alzheimer type (SDAT) and in 18 age matched controls. We calculated asymmetry indices (AIs) of rCBF for matched right-left regions of interest. rCBF of parietal lobe in SDAT patients was significantly most laterally asymmetrycal, but the least in occipital lobe. Lateral asymmetry of rCBF in SDAT patients correlated with asymmetry of language and visuospatial functions ; decreased rCBF in the left parietal lobe was associated with language dysfunction, and that in the right parietal lobe, with visuospatial dysfunction. Furthermore cerebellar AIs correlated negatively with those of the cerebral hemisphere and lower frontal region in SDAT patients. The results demonstrate that rCBF measurement by 123I-IMP SPECT is useful to detect lateral asymmetry in reduction of rCBF in SDAT. |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl-p-[123I]iodoamphetamine, single photon emission computed tomography, senile dementia of Alzheimer type, asymmetry, crossed cerebellar diaschisis. |
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