| Japanese |
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| Title | 99mTc標識アルブミンによる蛋白漏出性胃腸症のRIイメージング診断 |
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| Subtitle | 原著 |
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| Authors | 柏木徹*, 福井弘幸*, 上甲剛*, 小塚隆弘*, 木村和文**, 笠原彰紀***, 佐藤信紘***, 鎌田武信***, 尾崎由和****, 位田忍****, 田尻仁****, 野瀬宰****, 岡田伸太郎**** |
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| Authors(kana) | |
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| Organization | *大阪大学医学部中央放射線部, **バイオメディカル教育研究センター, ***第一内科, ****小児科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 12 |
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| Page | 1361-1368 |
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| Year/Month | 1990/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」蛋白漏出性胃腸症6例, 非蛋白漏出性胃腸症3例に99mTc標識アルブミンを静注して腹部シンチグラフィによる蛋白漏出のイメージング診断を行った. 蛋白漏出性胃腸症6例中3例で99mTc標識アルブミン静注3時間後に回腸が描出, 残り3例でも24時間後に大腸が明瞭に描出され, 全例で蛋白の腸管内漏出がイメージとして実証された. 一方, 非蛋白漏出性胃腸症の3例では24時間後に至るも腸管内へのRI集積を認めなかった. 正常人における99mTc標識アルブミン経口投与の検討では投与24時間後に至るも腸管像のみが明瞭に描出され, 腸管内に漏出した99mTcが腸から吸収される可能性は乏しいと考えられた. 以上から99mTc標識アルブミンによる腹部シンチグラフィは簡便で, 蛋白漏出性胃腸症の新しい診断法になり得ると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Protein-losing gastroenteropathy, Abdominal scintigraphy, 99mTc-HSA, 99mTc-HSA-D. |
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| English |
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| Title | Imaging Diagnosis of Protein-Losing Enteropathy by 99mTc-labeled Serum Albumin |
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| Subtitle | Original Articles |
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| Authors | Toru KASHIWAGI*, Hiroyuki FUKUI*, Takeshi JYOKOU*, Takahiro KOZUKA*, Kazufumi KIMURA**, Akinori KASAHARA***, Nobuhiro SATO***, Takenobu KAMADA***, Yoshikazu OZAKI****, Shinobu IDA****, Hitoshi TAJIRI****, Osamu NOSE****, Shintaro OKADA**** |
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| Authors(kana) | |
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| Organization | *Central Clinic of Radiology, Osaka University Hospital, **Biomedical Reserch Center, Osaka University Medical School, ***First Department of Medicine, Osaka University Medical School, ****Department of Pediatrics, Osaka University Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 12 |
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| Page | 1361-1368 |
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| Year/Month | 1990/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Abdominal scintigraphy with intravenous injection of 99mTc-labeled serum albumin was performed in 6 patients with protein-losing enteropathy (PLE) and 3 patients with nongastrointestinal tract disorders. In 3 out of 6 patients with PLE, abnormal radioactivity was observed in the ileum region 3 hours after injection, and thereafter clear colon image was obtained. In the remaining 3 patients, the colon was visualized 24 hours after injection. On the other hand, in all patients with nongastrointestinal tract disorders, no abnormal radioactivity was observed in the abdomen until 24 hours after injection. These results indicate that gastrointestinal protein loss could be demonstrated by scintigraphy with intra-venously administered 99mTc-labeled serum albumin. In one healthy subject, 99mTc-labeled serum albumin was administered orally and abdominal scintigraphy was performed. Gastrointestinal tract image was only observed and no other image was demonstrated until 24 hours after oral administration. This result suggests that 99mTc excreted into the gastrointestinal tract is not reabsorbed. Therefore, abdominal scintigraphy with 99mTc-labeled serum albumin appears to be a simple and useful method for diagnosis of PLE. |
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| Practice | Clinical medicine |
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| Keywords | Protein-losing gastroenteropathy, Abdominal scintigraphy, 99mTc-HSA, 99mTc-HSA-D. |
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