| Japanese |
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| Title | 大視野ガンマカメラを用いたN-isopropyl-p-[123] iodoamphetamineによる脳血流SPECTの簡便な定量化法 |
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| Subtitle | 《研究速報》 |
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| Authors | 米倉義晴*, 岩崎康**, 藤田透**, 笹山哲**, 的場直樹**, 定藤規弘**, 玉木長良**, 小西淳二** |
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| Organization | *京都大学医学部脳病態生理学講座, **核医学講座 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 11 |
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| Page | 1311-1316 |
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| Year/Month | 1990/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脳血流SPECT製剤として広く利用されているN-isopropyl-p-[123I]iodoamphetamine(IMP)を用いた簡便な脳血流の定量化法を考案した. IMPの脳における挙動をマイクロスフェアと仮定し, 大視野のガンマカメラを用いて, 肺および脳における経時的な変化から全身に送り出されたIMPの脳への取り込み率(FU)を算出した. FUは, 体表面積の逆数と強い正の相関を示し, FUが心拍出量に依存した値であることを示唆した. この値をもとに, 投与20分後より撮像したSPECT画像から算出した局所脳血流量の指標は, PETを用いて測定した局所脳血流量よりもやや高値を示す傾向を認めた. 本法は, 大視野のガンマカメラを持つ施設であればどこでも施行できる利点があるが, 体格の大きな例や心肺疾患例における測定には問題があり, その測定の精度と限界についてはさらに今後の検討が必要である. |
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| Practice | 臨床医学：一般 |
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| Keywords | SPECT, cerebral blood flow, N-isopropyl-p-[123I]iodoamphetamine, gamma camera, dynamic imaging |
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| English |
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| Title | Simple Quantification of Brain Perfusion SPECT with IMP Using a Large Field Gamma Camera |
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| Subtitle | |
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| Authors | Yoshiharu YONEKURA*, Yasushi IWASAKI**, Toru FUJITA**, Satoshi SASAYAMA**, Naoki MATOBA**, Norihiro SADATO**, Nagara TAMAKI**, Junji KONISHI** |
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| Authors(kana) | |
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| Organization | *Department of Brain Pathophysiology, **Department of Nuclear Medicine, Kyoto University Faculty of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 11 |
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| Page | 1311-1316 |
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| Year/Month | 1990/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We have developed a simple method to quantitate brain perfusion SPECT with N-isopropyl-p-[123I]iodoamphetamine (IMP). After an intravenous bolus injection of IMP, serial dynamic images of the brain and the lung were obtained every 5 sec for 2 min, followed by a SPECT scan at 20 min. Based on the assumption of IMP as chemical microspheres, fractional uptake (FU) of IMP in the brain was calculated from the time-activity curves of the total brain and the total lungs. FU showed a strong positive correlation with inverse of the body surface area which was calculated from the height and weight of the individual subject, suggesting that FU is influenced by cardiac output. Quantification of IMP brain perfusion SPECT was attempted with FU and estimated cardiac output in each subject, providing an index of regional cerebral blood flow. Compared with PET measurement of regional cerebral blood flow, the present method tended to overestimate the flow values. This method has a great advantage that it can be applied in many institutions having large field gamma cameras. However, the accuracy of the measurement may be limited in the tall subjects and in the cases with cardiopulmonary diseases, and further investigation is required to clarify the usefulness and limitation of this approach. |
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| Practice | Clinical medicine |
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| Keywords | SPECT, cerebral blood flow, N-isopropyl-p-[123I]iodoamphetamine, gamma camera, dynamic imaging |
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