| Japanese |
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| Title | I-123 metaiodobenzylguanidine (MIBG) の心筋内washoutに関する検討 |
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| Subtitle | 《原著》 |
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| Authors | 斎藤富善*, 渡辺直彦*, 斎藤恒儀*, 浅倉司*, 菅家道人*, 大和田憲司*, 星宏治**, 木村和衛**, 丸山幸夫* |
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| Organization | *福島県立医科大学第一内科, **核医学科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 11 |
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| Page | 1301-1306 |
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| Year/Month | 1990/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心筋ファントムおよび心疾患例にI-123 MIBG(n=6)とTl-201(n=6)を投与しSPECT撮像後, 体軸横断像を再構成し, ROI法によりcrosstalkを検討した. I-123からTl-201のウィンドウへはファントムで35±30%, 症例においては初期で30±10%, 後期で33±7%と各部位, 各症例さらに各時期で異なりcrosstalkの一律補正は困難と考えられた. Tl-201からI-123へはおのおの1%程度であった. 健常例(N, n=3), 心筋梗塞症(MI, n=10), 拡張型心筋症(DCM, n=4)にI-123 MIBGとTl-201をcrosstalkを避けるため別の日に投与し, 15分後と4時間後像より心筋灌流状態の定量化の指標であるTl-201のwashout rate(WR)を求めた. 同様の方法で, I-123 MIBGのWRも算出し交感神経機能評価を試みた. 心筋全体のTl-201のWRは, 各群とも36%とほぼ一定であったが, MIBGのWRはN群(24±7%)よりMI群(41±14%), さらにDCM群(52±7%)で有意に高値であった. MI群では負荷による影響はI-123 MIBGよりTl-201で有意に大であった. 以上よりI-123 MIBGのWRはTl-201のWRとは違った情報を提供し, 交感神経機能異常を半定量的に表すことが可能になる有用な指標と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | MIBG, Washout rate, Crosstalk, Myocardial infarction, Dilated cardiomyopathy. |
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| English |
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| Title | Estimation of I-123 Metaiodobenzylguanidine (MIBG) Myocardial Washout |
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| Authors | Tomiyoshi SAITO*, Naohiko WATANABE*, Tsuneyoshi SAITOH*, Tsukasa ASAKURA*, Michito KANKE*, Kenji OWADA*, Kouji HOSHI**, Kazue KIMURA**, Yukio MARUYAMA* |
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| Authors(kana) | |
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| Organization | First Department of Internal Medicine, **Department of Nuclear Medicine, Fukushima Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 11 |
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| Page | 1301-1306 |
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| Year/Month | 1990/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | A crosstalk from I-123 to Tl-201 (T1) window was 35+-30% (mean+-SD) and 30+-10% in a myocardial phantom and the images of 6 patients respectively. However, the crosstalk from Tl to I-123 was approximately 1% in each. I-123 MIBG (MIBG) and Tl myocardial SPECT images were recorded in 3 normal volunteers (N), 10 patients with myocardial infarction (MI), and 4 with dilated cardiomyopathy (DCM). The MIBG and Tl imagings were performed on the other day to avoid the crosstalk. Myocardial washout rates (WR) of Tl and MIBG were derived from 15 min and 4 hour images. WR of Tl was approximately 36% in each group. On the other hand, WR of MIBG in DCM (52+-7%) and MI (41+-14%) groups were statistically higher than in N (24+-7%) group. Thus WR of MIBG would be useful to detect abnormalities in adrenergic nervous system. |
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| Practice | Clinical medicine |
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| Keywords | MIBG, Washout rate, Crosstalk, Myocardial infarction, Dilated cardiomyopathy. |
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