Japanese
Title超微粒子放射性エロソール (テクネガス) による吸入肺シンチグラフィ
Subtitle《原著》
Authors井沢豊春*, 手島建夫*, 穴沢予識*, 三木誠*, 本宮雅吉*
Authors(kana)
Organization*東北大学抗酸菌病研究所内科
Journal核医学
Volume27
Number11
Page1273-1280
Year/Month1990/11
Article原著
Publisher日本核医学会
Abstract「要旨」正常者4名, 各種肺疾患患者31名を対象に, テクネガスによる吸入肺スキャンを行った. 残気量位から全肺容量位まで, 深吸気ののち息止めさせる方法で吸入させると, 肺胞沈着率は85%に達した. 高い肺胞沈着率のために吸入から撮像までの時間にゆとりがあり, 吸入後70分まではほとんど同じ画質の画像が得られた. 血流肺スキャンと比べると, 両者はほぼ1対1に対応して, テクネガスの吸入肺スキャンは肺の有効換気領域を示すと考えられた. 癌や閉塞性肺疾患では, 気道狭窄部位で, “hot spot”を形成することがあり, テクネガスはガスに近い性質と, エロソールとしての性質を示した. テクネガスの吸入の前後で血液生化学, 末梢血, 尿, 血圧, 脈拍などに変化がなかった. ただし, テクネガス生成直後は, 無酸素状態なので, 生成直後に限って, 吸入法に工夫を要し, 機器の設計上改善の余地があるものと考えられる.
Practice臨床医学：一般
KeywordsAlveolar deposition ratio, Inhalation lung imaging, Perfusion lung imaging, Technegas, 99mTc-pertechnetate.
English
TitleRadioaerosol Inhalation Lung Imaging using Technegas
Subtitle- Original Articles -
AuthorsToyoharu ISAWA, Takeo TESHIMA, Yoshiki ANAZAWA, Makoto MIKI, Masakichi MOTOMIYA
Authors(kana)
OrganizationDepartment of Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University
JournalThe Japanese Journal of nuclear medicine
Volume27
Number11
Page1273-1280
Year/Month1990/11
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractTechnegas generator using 99mTc-pertechnetate was tested on 4 normal subjects and 31 patients with various chest diseases including bronchogenic carcinoma, pneumonia, pulmonary tuberculosis, sarcoidosis, and so on. Technegas was inhaled from the RV to the TLC levels through the mouth with the nose clipped followed by breath-holding. Three deep breaths were enough to deposit 37-55.5 MBq (1 to 1.5 mCi) of technegas in the lungs. The average alveolar deposition ratio (ALDR) was 85% and penetration of inhaled technegas to the lung periphery was excellent. "Hot spots" or excessive radioactive deposition were also seen when there was airway obstruction. The former indicated the characteristic as gas and the latter, that as aerosol particles. Because of the large ALDR's the timing for imaging lungs after inhalation of technegas was not critical. Inhalation lung images most likely indicated the intrapulmonary sites of effective ventilation, because respective inhalation and perfusion lung images resembled each other very much. The disadvantage of technegas was that it was anoxic right after generation.
PracticeClinical medicine
KeywordsAlveolar deposition ratio, Inhalation lung imaging, Perfusion lung imaging, Technegas, 99mTc-pertechnetate.

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