| Japanese |
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| Title | 心筋症・心筋炎における111In-標識抗ミオシンモノクローナル抗体シンチグラフィ |
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| Subtitle | 《原著》 |
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| Authors | 松森昭*, 山田武彦*, 森島繁*, 玉木長良**, 渡辺祐司**, 米倉義晴**, 遠藤啓吾**, 小西淳二**, 吉田章***, 河合忠一* |
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| Authors(kana) | |
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| Organization | *京都大学医学部第三内科学教室, **核医学教室, ***三菱京都病院 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 10 |
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| Page | 1129-1134 |
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| Year/Month | 1990/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心筋症・心筋炎における抗ミオシンモノクローナル抗体シンチグラフィを病型別に比較検討した. 拡張型心筋症(DCM)10例, 肥大型心筋症(HCM)7例(うち拡張相3例), 心筋炎(MC)9例, 計26例を対象とした. 74 MBq(2 mCi)のインジウム111標識抗ミオシン抗体を静注し, 48時間後にプラナー像およびSPECT像を撮像した. 心筋への取り込みは(1)視覚的判定および(2)心/肺比の算出にて評価した. 視覚的判定による陽性率はDCM 70%, HCM 86%(うち拡張相100%), MC 1か月以内100%, 2か月以降14%であった. DCMで高度の集積を認めた3例およびHCMの1例はその後死亡した. DCMおよびHCMにおける心/肺比は左室拡張末期径と正の相関を示し, 左室駆出率とは負の相関を示した. 本法は, 心筋症・心筋炎における心筋細胞障害の存在の有無や, 予後の評価に有用である可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Cardiomyopathy, Myocarditis, 111In-antimyosin, Monoclonal antibody, Scintigraphy. |
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| English |
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| Title | Indium-111 Antimyosin Monoclonal Antibody Uptake in Patients with Cardiomyopathy and Myocarditis |
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| Subtitle | - Original Articles - |
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| Authors | Akira MATSUMORI*, Takehiko YAMADA*, Shigeru MORISHIMA*, Nagara TAMAKI**, Yuji WATANABE**, Yoshiharu YONEKURA**, Keigo ENDO**, Junji KONISHI**, Akira YOSHIDA***, Chuichi KAWAI* |
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| Authors(kana) | |
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| Organization | *The Third Division, Department of Internal Medicine, **Department of Nuclear Medicine, Kyoto University Faculty of Medicine, ***Mitsubishi Kyoto Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 10 |
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| Page | 1129-1134 |
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| Year/Month | 1990/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Prognostic significance of myocardial uptake of indium-111 antimyosin antibody was evaluated in 17 patients with idiopathic cardiomyopathy; 10 patients with dilated cardiomyopathy and 7 patients with hypertrophic cardiomyopathy. Seven of 10 patients with dilated cardiomyopathy showed positive images. Three of these 7 patients with strongly positive scans died after scintigraphic examination. Six of 7 patients with hypertrophic cardiomyopathy showed positive images. Three of the patients with dilated left ventricle had prominent positive scans and higher heart to lung ratio. The heart to lung ratio of antimyosin uptake in total patients was correlated with left ventricular end-diastolic dimension and ejection fraction measured by echocardiography. In patients with myocarditis, all three patients showed positive scintigrams within 4 weeks after the onset of the disease and 1 of 6 patients was positive thereafter, who had dilated ventricle and decreased cardiac function. Thus, indium-111 antimyosin antibody imaging may be useful to evaluate prognosis of patients with cardiomyopathy and myocarditis. |
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| Practice | Clinical medicine |
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| Keywords | Cardiomyopathy, Myocarditis, 111In-antimyosin, Monoclonal antibody, Scintigraphy. |
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