| Japanese |
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| Title | 99mTc-アルブミン肺分布率および201Tl肺摂取率による肺血管内・肺血管外スペースの評価 |
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| Subtitle | 《原著》 |
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| Authors | 藤井忠重*, 田中正雄*, 本郷実*, 中塚龍也*, 平山二郎*, 広瀬芳樹*, 吉村一彦*, 大久保信一*, 小林俊夫*, 半田健次郎*, 矢野今朝人**, 横田憲一** |
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| Authors(kana) | |
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| Organization | *信州大学医学部第一内科, **中央放射線部 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 10 |
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| Page | 1109-1117 |
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| Year/Month | 1990/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心疾患において99mTc-アルブミン(HSA)および201Tl(Tl)のシンチグラフィから1側肺と両肺当たりのHSA分布率およびTl肺摂取率を算出し, その意義を検討した. HSA肺分布率とTl肺摂取率は心拍出量, 心係数と負の相関を, また, Tl肺摂取率は肺動脈楔入圧と正の相関を示した. 両指標およびTl肺摂取率/HSA肺分布率の比は心不全(+)の心疾患で, また, Tl肺摂取率は心不全(-)の心疾患で有意な高値を示した. 両指標は相関を示したが, 明らかなミスマッチも認められ, 局所肺での201Tl分布と肺血流分布もほぼ同様な関係を示した. 本法は同一条件下に肺全体および局所肺における肺血管内スペースと肺血管外スペースの大きさを描画・定量化でき, 心疾患の病態を評価する一助になる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Pulmonary intravascular space, Pulmonary extravascular space, Scintigraphy, 201Tl, 99mTc-albumin. |
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| English |
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| Title | Estimation of Pulmonary Intravascular and Extravascular Spaces by 99mTc-Albumin Lung Distribution Ratio and 201Tl Lung Uptake Ratio |
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| Subtitle | - Original Articles - |
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| Authors | Tadashige FUJII*, Masao TANAKA*, Minoru HONGO*, Jiro HIRAYAMA*, Yoshiki HIROSE*, Shinichi OKUBO*, Toshio KOBAYASHI*, Kenjiro HANDA*, Kesato YANO**, Kenichi YOKOTA** |
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| Authors(kana) | |
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| Organization | *The First Department of Internal Medicine, **Division of Radiology, Shinshu University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 10 |
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| Page | 1109-1117 |
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| Year/Month | 1990/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | In order to estimate the pulmonary extravascular and intravascular spaces, lung uptake ratio of 201Tl (L/T) and lung distribution ratio of 99mTc-albumin (H/T'), expressed as ratios of total counts of the bilateral lungs to the administered doses of the radionuclides, were obtained from the both scintigrams with 201Tl and 99mTc-albumin respectively, using a scintillation camera coupling to a minicomputer. Mean values of L/T and H/T' were 2.8+-0.8% and 4.9+-1.4% in the controls, 3.9+-1.8% and 5.3+-1.9% in heart diseases without left heart failure, and 7.0+-2.2% and 7.1+-2.9% in those with left heart failure, respectively. Ratios of L/T to H/T' in diffuse interstitial pneumonia and heart diseases, especially in cases with left heart failure were higher than those in controls. The values of H/T' and L/T were inversely proportional to cardiac output and cardiac index, and the values of L/T were directly proportional to pulmonary artery wedge pressure, but the discrepancies of the relationship between these values and some clinical findings including cardiac output, cardiac index, pulmonary artery wedge pressure and other findings of left heart failure, were observed in not a few cases. In the regional pulmonary areas, lung uptake of 201Tl was in parallel with pulmonary perfusion in many cases, but the discrepancies between them were demonstrated in some cases, too. These methods seem to be useful for the estimation of the pulmonary extravascular and extravascular spaces, and for the detection of dysfunction of the left ventricle. |
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| Practice | Clinical medicine |
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| Keywords | Pulmonary intravascular space, Pulmonary extravascular space, Scintigraphy, 201Tl, 99mTc-albumin. |
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