| Japanese |
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| Title | 123I-IMP肺クリアランスの喫煙による影響 |
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| Subtitle | 《原著》 |
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| Authors | 加藤邦彦*, 高橋恒男* |
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| Organization | *岩手医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 10 |
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| Page | 1093-1098 |
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| Year/Month | 1990/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」IMPは活性アミンの1つであり肺で代謝を受けるが, 肺病変によりその代謝過程に異常をおこすと考えられる. 今回, われわれは健康な非喫煙者5名と喫煙者9名を対象に123I-IMP肺シンチグラフィを行い, 123I-IMPの肺内動態を比較検討した. 123I-IMP 111 MBq(3 mCi)を肘静脈から急速静注し, 1 frame/minで60分間のデータ収集を行い各pixelごとの時間放射能曲線をC(t)=A1e-klt+A2e-k2tの2コンパートメントモデルにて解析した. その結果, 喫煙者では非喫煙者に比して有意に123I-IMPの肺からの洗い出しの遅延を認め, また洗い出し率と1日の喫煙本数との間に良好な負の相関がみられ喫煙による急性肺障害が示唆された. 123I-IMP肺シンチグラフィは, 喫煙による肺障害を非侵襲的に早期に見つける可能性があると思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, cigarette smoking, lung metabolic disorder. |
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| English |
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| Title | Effects of Cigarette Smoking on I-123 IMP Clearance from the Lung |
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| Subtitle | - Original Articles - |
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| Authors | Kunihiko KATOH, Tsuneo TAKAHASHI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Iwate Medical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 10 |
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| Page | 1093-1098 |
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| Year/Month | 1990/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | N-isopropyl-p-I-123-iodoamphetamine (I-123 IMP), originally developed as a brain scanning agent, is also taken up by the lung. To evaluate the cigarette smoking on the uptake of IMP by the lung, we studied I-123 IMP clearance from the lung on 14 volunteers; 5 non-smokers and 9 smokers. After the injection of 111 MBq (3 mCi) of I-123 IMP into the medial cubital vein, the time-activity curve for 60 minutes and the regional activity using 1 frame per minute and a 64×64 matrix was obtained. I-123 IMP clearance curve was described as follows: C(t)=A1e-klt+A2e-k2t (A1, A2: intercepts, and k1, k2: slopes of the exponential components). I-123 IMP clearance was delayed in smokers, and k2 was smaller in smokers. Also a significant correlations between k1, k2, and the number of cigarettes smoked per day were found, In conclusion, this study suggests that the delayed clearance and retention of I-123 IMP in the lung indicate the lung metabolic disorders due to cigarette smoking. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, cigarette smoking, lung metabolic disorder. |
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