Japanese
Title筋萎縮性側索硬化症における123I-IMP脳血流シンチグラフィ所見
Subtitle《症例報告》
Authors安斎恵美子*, 塩澤全司*, 新藤和雅*, 角田伸一*, 小泉潔**, 内山暁**
Authors(kana)
Organization*山梨医科大学第三内科学教室, **放射線医学教室
Journal核医学
Volume27
Number8
Page863-867
Year/Month1990/8
Article報告
Publisher日本核医学会
Abstract「要旨」筋萎縮性側索硬化症(ALS)の患者3名にIMP-SPECTによる検討を行なった. 症例1は31歳の男性で両上肢筋力低下があり, 両下肢痙性麻痺を認め, 球症状も強かった. 症例2は51歳の女性で両上肢筋力低下があり, 球症状が強かった. 症例3は68歳の男性で両上肢筋力低下があり, 球症状がみられた. 3例はともに臨床上ALSと診断され, 痴呆を認めず, 大脳高次機能は正常だった. CTおよびMRIでは, 症例1は前頭部から頭頂部にかけて広範な中等度の進行性脳萎縮をみたが, 他の2例は正常所見だった. IMP-SPECTでは3例とも前頭頭頂部に血流低下を認めた. ALSで慢性進行性の脳血流低下が存在する可能性が示唆された. 「I. はじめに」N-isopropyl-p-[123I]iodoamphetamine(123I-IMP)によるsingle photon emission computed tomography(SPECT)は局所脳血流量を容易に評価することが可能で, 脳血管障害, てんかん, アルツハイマー病のみならず, パーキンソン病や脊髄小脳変性症などの変性疾患にも臨床応用されている.
Practice臨床医学：一般
Keywords123I-IMP SPECT amyotrophic lateral sclerosis, motor cortex, hypoperfusion, cognitive function.
English
Title123I-iodoamphetamine Single Photon Emission Computed Tomography in Three Patients with Amyotrophic Lateral Sclerosis
Subtitle- Case Reports -
AuthorsEmiko ANZAI*, Zenji SHIOZAWA*, Kazumasa SHINDO*, Shin-ichi TSUNODA*, Kiyoshi KOIZUMI**, Guio UCHIYAMA**
Authors(kana)
Organization*Third Department of Medicine, Yamanashi Medical University, **Department of Radiology, Yamanashi Medical University
JournalThe Japanese Journal of nuclear medicine
Volume27
Number8
Page863-867
Year/Month1990/8
ArticleReport
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractWe examined the 123I-iodoamphetamine SPECT for 3 patients with ALS, who were clinically diagnosed. Patient 1 was a 31-years-old man, who had bilateral muscle weakness of his upper extremities, and spastisity in lower extremities. Patient 2 was a 51-years-old woman, who had marked weakness of her upper extremities and bulbar sign. Patient 3 was a 68-years-old man, who had severe degree of marked weakness of his upper extremities and mild bulbar signs. Cerebral cognitive function were all normal in three patients. Computed tomographic and magnetic resonance imagings showed moderate degree of cortical atrophy in patient 1, but no abnormalities in patients 2 and 3. In 123I-IMP SPECT, however, hypoperfusion were recognized on the bilateral fronto-parietal border zone areas in these three patients with ALS. It was suggested that patients with ALS showed varying degrees of impaired perfusion in the fronto-parietal border zone areas in spite of normal cognitive functions.
PracticeClinical medicine
Keywords123I-IMP SPECT amyotrophic lateral sclerosis, motor cortex, hypoperfusion, cognitive function.

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