| Japanese |
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| Title | 111In標識自家血小板による特発性血小板減少性紫斑病における血小板動態の検討 |
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| Subtitle | 《原著》 |
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| Authors | 井坂吉成*1, 上林純一*2, 木村和文*3, 上原章*4, 橋川一雄*4, 松本昌泰*5, 鎌田武信*5, 今泉昌利*1, 芦田敬一*1, 中山博文*1, 松下幸司*1, 古川俊之*1 |
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| Authors(kana) | |
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| Organization | *1国立大阪病院循環器科, *2大阪大学医学部第二外科, *3生体情報部門, *4中央放射線部, *5第一内科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 8 |
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| Page | 855-861 |
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| Year/Month | 1990/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」未治療の特発性血小板減少性紫斑病12例と健常例8例において, 111In-自家血小板による血小板交代率, 血小板寿命, 血小板の生体内分布, さらに血小板の産生と崩壊のバランスを検討するために血小板交代率と標識血小板の脾臓および肝臓の放射能の総和の比率(platelet production/clearance index)を比較した. 血小板数と血小板寿命の間には有意の正相関が認められた. 脾臓と肝臓の放射能の総和と血小板寿命の間に逆相関を認めた. platelet production/clearance indexと血小板数の間には全例の比較で正相関を認めた. 血小板交代率は12例中8例において低下が認められたが, 血小板数と血小板交代率の間には有意の相関が認められなかった. 特発性血小板減少性紫斑病の重症度に影響を与える因子として網内系における血小板の破壊機転が最も重要であるが, 血小板の産生低下が血小板減少に与える影響も無視できないことが結論できた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Thrombocytopenia, ITP, survival, 111In-platelets, platelet turnover, |
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| English |
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| Title | Platelet Production, Clearance and Distribution in Patients with Idiopathic Thrombocytopenic Purpura |
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| Subtitle | - Original Articles - |
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| Authors | Yoshinari ISAKA1, Junichi KAMBAYASHI2, Kazufumi KIMURA3, Akira UEHARA4, Kazuo HASHIKAWA4, Masayasu MATSUMOTO5, Takenobu KAMADA5, Masatoshi IMAIZUMI1, Keiichi ASHIDA1, Hirofumi NAKAYAMA1, Koji MATSUSHITA1, Toshiyuki FURUKAWA1 |
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| Authors(kana) | |
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| Organization | 1Department of Cardiovascular Medicine, Osaka National Hospital, 2Second Department of Surgery, 3Biomedical Research Center, 4Division of Nuclear Medicine, And 5First Department of Internal Medicine, Osaka University Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 8 |
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| Page | 855-861 |
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| Year/Month | 1990/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We have studied 8 normal subjects, and 12 patients with idiopathic thrombocytopenic purpura whose platelet counts ranged from 9×109/L to 40×109/L. Autologous platelets labeled with 111In-tropolone were used for evaluation of mean platelet survival, platelet turnover, platelet sequestration sites, and platelet production (turnover) to clearance (sum of platelet uptake in the liver and the spleen) ratio. Platelet survival correlated directly with platelet counts. There was no significant correlation between the platelet sequestration pattern and platelet count, survival, or turnover. Sum of platelet uptake in the liver and the spleen showed a significant inverse correlation with platelet survival, No significant correlation was found between platelet turnover and platelet count. There was a significant correlation between the platelet production to clearance index when all subjects were analyzed. The distribution of platelet turnover showed considerable individual variation; eight of twelve patients showed platelet turnover less than mean minus 2SD of the control value, but others showed normal range. We conclude that although platelet destruction mechanism in RES shows a primary role of thrombocytopenia, impaired rate of effective thrombopoiesis may also contribute to disease severity in ITP. |
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| Practice | Clinical medicine |
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| Keywords | Thrombocytopenia, ITP, survival, 111In-platelets, platelet turnover, |
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