| Japanese |
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| Title | 虚血性心疾患における123I-MIBGシンチグラムの有用性 - 201Tl-Cl心筋シンチグラムとの比較検討 - |
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| Subtitle | 《原著》 |
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| Authors | 佐藤圭子*, 加藤健一**, 村田啓*, 西村重敬**, 川口洋*** |
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| Organization | *虎の門病院放射線科, **循環器病センター, ***順天堂大学循環器内科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 8 |
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| Page | 821-831 |
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| Year/Month | 1990/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」虚血性心疾患, 特にNon-Q wave myocardial infarction(NQMI)における, 201Tl-Cl(Tl)と123I-metaiodobenzylguanidine(MIBG)の運動負荷心筋SPECTを, 異常領域の広がりと異常度をBull's eye mapをもとにscore化し, 比較検討した. Q wave myocardial infarction(QMI)群, NQMI群, 狭心症群において, MIBG異常scoreはTl異常scoreに比し高値を示し, 特にNQMI群, 狭心症群では有意差を認めた. さらに, 局所壁運動がhypokinesisを呈した部位で, Tl異常域出現率は42%であるのに対しMIBGは100%であった. MIBGシンチグラムはTlに比し軽度の心筋虚血障害も鋭敏に検出することが可能と思われた. さらにstunned myocardiumを呈したNQMI例のうち, 陰性T波と壁運動異常の存在する時期の症例群と, それらが改善した時期の症例群とを比較すると, 前者は後者に比し, MIBG異常域の広さ, 異常度が有意に高かった. 陰性T波, stunned myocardiumの成因の1つに, 交感神経機能異常の関与が示唆された. 以上より, 虚血性心疾患の臨床診断に, MIBGシンチグラムは有用と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-MIBG scintigraphy, 201Tl-Cl scintigraphy, Ischemic heart disease, Non-Q wave myocardial infarction, stunned myocardium. |
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| English |
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| Title | Assessment of Ischemic Damage of the Cardiac Sympathetic Nerve Function by Semiquantitative Analysis of 123I-MIBG (metaiodobenzylguanidine)-SPECT - Comparison with 201Tl-Cl-SPECT - |
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| Subtitle | - Original Articles - |
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| Authors | Keiko SATOH*, Kenichi KATOH**, Hajime MURATA*, Shigeyuki NISHIMURA**, Hiroshi YAMAGUCHI*** |
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| Authors(kana) | |
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| Organization | *Division of Nuclear Medicine, **Cardiovascular Center, Toranomon Hospital, ***Division of Cardiology, Department of Internal Medicine, Juntendou University of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 8 |
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| Page | 821-831 |
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| Year/Month | 1990/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Recently 123I-MIBG sintigraphy has been developed for evaluating the function of cardiac sympathetic nerve. To assess its ischemic damage, dual SPECT with 123I-MIBG and 201Tl-Cl were performed in 24 patients with ischemic heart disease and 8 normal subjects. In order to evaluate extent and severity of ischemic damage, Tl and MIBG abnormal scores were culculated by Bull’s eye map. In patients with Non-Q wave myocardial infarction (NQMI), MIBG abnormal scores were significantly higher than Tl scores (p<0.01). In the regions where regional wall mortion showed hypokinesis, MIBG abnormalities were detected in all cases whereas Tl abnormalities existed only in 42%. MIBG abnormality score in NQMI group with negative T wave and wall mortion asynergy was significantly higher than that of NQMI group without T wave abnormality and asynergy (p<0.01). Ischemic damage of cardiac sympathetic nerve seemed to contribute to negative T wave and stunned myocardium. 123I-MIBG scintigraphy was thought to be a sensitive and useful method for Clinical evaluation of ischemic heart desease. |
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| Practice | Clinical medicine |
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| Keywords | 123I-MIBG scintigraphy, 201Tl-Cl scintigraphy, Ischemic heart disease, Non-Q wave myocardial infarction, stunned myocardium. |
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