| Japanese |
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| Title | 99mTc-テクネガスの基礎的検討と臨床応用 |
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| Subtitle | 《原著》 |
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| Authors | 川上憲司*, 岩村昇*, 後藤英介*, 森豊*, 阿部達之*, 平沢之規**, 石田博英**, 島田孝夫***, 富永滋**** |
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| Authors(kana) | |
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| Organization | *東京慈恵会医科大学放射線医学教室, **放射線科, ***第三内科, ****順天堂大学浦安病院内科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 7 |
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| Page | 725-733 |
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| Year/Month | 1990/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-テクネガスの体内挙動および臨床応用について, 正常ボランティア3名および種々肺疾患例10例を対象として検討した. 血液中の放射能は, 2時間後において吸入量の0.2%/l血液であった. 尿中放射能は24時間後においても吸入量の4.96%であった. 肺における99mTc-テクネガスの生物学的半減期は135時間であり, 肺のイメージは24時間後においても安定していた. 肺の被曝量は0.004Gy/37MBq(1mCi)であった. 肺疾患例における99mTc-テクネガスの分布は81mKr分布に類似していたが, 換気障害は99mTc-テクネガスにおいて鋭敏に検出された. エロゾル検査との比較では99mTc-テクネガスがより末梢まで分布しエロゾル検査と99mTc-テクネガス検査は相補的関係にあった. 以上の結果より99mTc-テクネガスは換気検査にとって安全かつ有用な核種といえる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-technegas ventilation study, 133Xe, 81mKr, Radiolabelled ultrafine particle. |
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| English |
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| Title | Kinetics and Clinical Application of 99mTc-Technegas |
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| Subtitle | - Original Articles - |
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| Authors | Kenji KAWAKAMI*, Akira IWAMURA*, Eisuke GOTO*, Yutaka MORI*, Tatsuyuki ABE*, Yukinori HIRASAWA*, Hirohide ISHIDA*, Takao SHIMADA**, Shigeru TOMINAGA*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology Jikei University School Medicine, **The 3rd Department of Medicine Jikei Univercity School of Medicine, ***Department of Medicine Urayasu hospital Juntendo University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 7 |
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| Page | 725-733 |
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| Year/Month | 1990/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Biological characteristics and clinical utilization of 99mTc-technegas were evaluated in three normal volunteers and 10 patients with various pulmonary diseases. 99mTc-pertechnetate (296 MBq (8 mCi)) was injected in the crusible of 99mTc-technegas generator, and about 37 MBq (1 mCi) of 99mTc-technegas was inhaled in the lung by three times of deep inspiration. Blood activity was appeared immediately after inhalation of 99mTc-technegas and it was 0.2% of the inhaled dose/litter of blood after 2 hours. Urine activity was also increased after inhalation and cumulative dose was 4.96% of the inhaled dose after 24 hours. The tracer dose to distribution to the lung was about 95% of the total dose in whole body. Biological half time of 99mTc-technegas in the lung was 135 hours and pulmonary image was stable even after 24 hours. Radiation dose to the lung was 0.004 Gy/37 MBq (1 mCi). In patients with pulmonary disease, distribution of 99mTc-technegas was similar to that of 81mKr gas, although defect on 99mTc-technegas image was larger in severe obstructive disease. 99mTc-technegas study was superior over 133Xe gas study to identify the areas of ventilation abnormality more clearly, although quantitative evaluation was difficult in 99mTc-technegas study. On comparative study with 99mTc-aerosol, 99mTc-technegas distributed in more peripheral sites and both methods were cooperative for evaluation of ventilatory disturbance. These results suggest that 99mTc-technegas inhalation study is safe and useful method for ventilation study. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-technegas ventilation study, 133Xe, 81mKr, Radiolabelled ultrafine particle. |
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