| Japanese |
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| Title | 気管支喘息における123I-IMPの肺集積 - 初期取り込みと排泄遅延 - |
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| Subtitle | 《原著》 |
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| Authors | 池田英樹*, 小松幹雄*, 清野秀一*, 高橋敬治*, 安井昭二*, 鞠子美代子** |
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| Authors(kana) | |
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| Organization | *山形大学医学部内科学第一講座, **臨床検査医学講座 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 7 |
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| Page | 719-724 |
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| Year/Month | 1990/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-IMPは初回肺循環で肺毛細血管内皮に高率に取り込まれ, その後緩徐に再放出される. 今回, 肺毛細血管内皮細胞への初回循環での取り込みと123I-IMPの排泄遅延を対比し, 排泄遅延の因子を検討した. 対象とした気管支喘息患者では胸部X線写真で異常は見られなかったが, 正常群に比し排泄遅延が見られた. また疾患群で初期取り込みが不均一となる傾向があり, 肺毛細血管内皮細胞の取り込み能の変化の存在が考えられた. しかし初回循環での取り込みと排泄遅延との間に相関関係は見られず, 肺毛細血管内皮細胞の取り込み能の変化のみでは排泄遅延を説明しえなかった. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, bronchial asthma, pulmonary capillary endothelial cell. |
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| English |
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| Title | 123I-IMP Accumulation in the Lung with Bronchial Asthma - Early Uptake and Delayed Washout - |
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| Subtitle | - Original Articles - |
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| Authors | Hideki IKEDA*, Mikio KOMATSU*, Shuichi SEINO*, Keiji TAKAHASHI*, Shoji YASUI*, Miyoko MARIKO** |
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| Authors(kana) | |
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| Organization | *The First Department of Internal Medicine, and **The Department of Laboratory Medicine, Yamagata University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 7 |
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| Page | 719-724 |
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| Year/Month | 1990/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | 123I-IMP is taken up by the pulmonary capillary endothelial cells during the first pass through the lung, and is slowly released from them. To look up the factors which influence on the prolonged 123I-IMP retention in the diseased lung, we examined the correlation between the 123I-IMP uptake during the first pass and the 123I-IMP retention. Patients with bronchial asthma had no abnormal finding in the chest X-ray photograph. However 123I-IMP release from their lungs was delayed. Some patients show a tendency that 123I-IMP uptake during the first pass was uneven, which suggested the change in amine uptake function of endothelial cells. However their correlation coefficients between the uptake during the first pass and the prolonged retention were very small. It was considered that the prolonged 123I-IMP retention in the diseased lung was not explained only by the change in uptake function of pulmonary capillary endothelial cell. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, bronchial asthma, pulmonary capillary endothelial cell. |
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