| Japanese |
|---|
| Title | 拡張型心筋症における123I-MIBG心筋摂取率の経時的変化 |
|---|
| Subtitle | 《原著》 |
|---|
| Authors | 山門亨一郎*, 竹田寛*, 中川毅*, 北野外紀雄**, 二神康夫***, 小西得司***, 浜田正行***, 中野赳***, 市原隆**** |
|---|
| Authors(kana) | |
|---|
| Organization | *三重大学医学部放射線科, **中央放射線部, ***第一内科, ****東芝那須 |
|---|
| Journal | 核医学 |
|---|
| Volume | 27 |
|---|
| Number | 7 |
|---|
| Page | 703-708 |
|---|
| Year/Month | 1990/7 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」ノルエピネフリンの類似物質であるMetaiodobenzylguanidine(MIBG)の標識化合物123I-MIBGは心筋の交感神経機能の評価に有用性があるものと期待されている. 今回, われわれは拡張型心筋症(DCM)8例と対照人6例を対象として, 201Tl 111 MBq(3 mCi)および123I-MIBG 111 MBq(3 mCi)を同時投与し, プラナーイメージ前面像を投与後5時間まで各30分から60分ごとに計6回撮影し, 両核種のcross-talkを補正して心筋摂取率を求め, 比較検討した. DCMにおける123I-MIBGの1ピクセル当りの心筋摂取率は, 15分値では対照に対し有意差は認めなかったが, 3時間後の減少率は46.9±13.8%で, 対照の18.0±7.7%に対し, 有意に高値を示した(p<0.05). DCMにおける123I-MIBGの心筋減少率を経時的に検討すると, 投与後早期(45分以内)に有意の減少を示し(21.2±7.5% vs 5.3±4.0%, p<0.01), この時期における心筋からの急激な減少が3時間後における減少率の有意の増大に寄与しているものと考えられた. 一方, 201Tlの1ピクセル当りの心筋摂取率および経時的減少率に対照との有意差は認めず, 両群に心筋血流の差はないものと考えられた. これらの所見はDCMの病態として, 心筋血流変化よりも交感神経機能異常が前景にあることを示唆しており, 本法は本症の病態生理の把握, 重症度判定に有用であるものと思われた. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 123I-Metaiodobenzylguanidine (MIBG), dilated cardio myopathy, myocardial scintigram. |
|---|
| English |
|---|
| Title | Serial Change of 123I-Metaiodobenzylguanidine (MIBG) Myocardial Concentration in Patients with Dilated Cardiomyopathy |
|---|
| Subtitle | - Original Articles - |
|---|
| Authors | Kouichiro YAMAKADO*, Kan TAKEDA*, Tokio KITANO*, Tsuyoshi NAKAGAWA*, Yasuo FUTAGAMI**, Tokuji KONISHI**, Masayuki HAMADA**, Takeshi NAKANO**, Takashi ICHIHARA*** |
|---|
| Authors(kana) | |
|---|
| Organization | * Department of Radiology, **Department of First Internal Medicine, Mie University School of Medicine, ***Toshiba Nasu |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 27 |
|---|
| Number | 7 |
|---|
| Page | 703-708 |
|---|
| Year/Month | 1990/7 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | 123I-Metaiodobenzylguanidinc (MIBG) is expected to be useful agent for functional evaluation of the myocardial sympathetic innervation. The aim of this paper is to investigate serial change of 123I-MIBG myocardial concentration in patients (pts) with dilated cardiomyopathy (DCM) as compared with 201Tl uptake. Eight pts with DCM and six non-cardiac subjects (controls) were examined. After injection of 111 MBq (3 mCi) 201Tl and 111 MBq (3 mCi) 123I-MIBG, simultaneous myocardial imaging in anterior view was performed for both tracers in every 30-60 minutes during 5 hours (6 images). Myocardial uptake ratio per pixel to the injected dose was calculated for each tracer with background and cross-talk correction on each image. In pts with DCM, myocardial uptake ratio of 123I-MIBG did not differ significantly from that of controls. The washout of 123I-MIBG from the myocardium, however, was significantly increased in pts with DCM as compared with controls. The % decrease of the radioactivity in 3 hours was 46.9+-13.8% in DCM, whereas 18.0+-7.7% in controls (p<0.05). Especially, the decrease in the early phase (<1 hour) was significantly larger in DCM than controls (21.2+-7.5% vs 5.3+-4.0%, p<0.01). For 201Tl, on the other hand, neither uptake ratio nor washout rate, differed significantly between the two. In conclusion, the rapid washout of 123I-MIBG in the early phase may reflect some sympathetic dysfunction in pts with DCM. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 123I-Metaiodobenzylguanidine (MIBG), dilated cardio myopathy, myocardial scintigram. |
|---|