Japanese
Title局所脳ブドウ糖代謝病態を観察しえたクロイツヘルトヤコブ病の1症例
Subtitle《症例報告》
Authors宍戸文男*, 上村和夫*, 犬上篤*, 戸村則昭*, 日向野修一*, 藤田英明*, 田畑賢一*, 佐々木広*, 村上松太郎*, 菅野巖*, 福島一成**, 長田乾**
Authors(kana)
Organization*秋田県立脳血管研究センター放射線医学研究部, **神経内科学研究部
Journal核医学
Volume27
Number6
Page649-654
Year/Month1990/6
Article報告
Publisher日本核医学会
Abstract「要旨」臨床症状と脳波所見からCreutzfeldt-Jakob diseaseと診断された症例の経時的な局所脳ブドウ糖消費量測定を, PETと18FDG法を用いて行った. X線CTにて脳萎縮が軽度であった時期の測定で, 正常者の平均約45%にまで脳ブドウ糖消費量が低下していた. 代謝の低下は大脳皮質に強く, 線条体・小脳・脳幹では低下が軽度であり, 大脳皮質でも運動野や後頭葉では代謝が比較的保たれていた. 病状が進行し脳萎縮が著明になった時期には, 大脳皮質の代謝低下はさらに進行するが, 基底核・脳幹・小脳核の代謝低下の進行は軽度であった. これらの所見はこれまでの剖検により得られた所見と異なる点があり, 本疾患の病態生化学的診断や病変の進行把握解明にPETによる局所脳代謝測定は非常に有用であると考えられた.
Practice臨床医学:一般
KeywordsCreutzfeldt-Jakob disease, Cerebral glucose metabolism, Positron emission tomography.
English
TitleBrain Glucose Metabolism in a Patient with Creutzfeldt-Jakob Disease Measured by Positron Emission Tomography
Subtitle
AuthorsFumio SHISHIDO*, Kazuo UEMURA*, Atsushi INUGAMI*, Noriaki TOMURA*, Shuuichi HIGANO*, Hideaki FUJITA*, Ken-ichi TABATA*, Hiroshi SASAKI*, Matsutarou MURAKAMI*, Iwao KANNO*, Kazunari FUKUSHIMA**, Ken NAGATA**
Authors(kana)
Organization*Department of Radiology and Nuclear Medicine, **Department of Neurology, Research Institute for Brain and Blood Vessels-Akita
JournalThe Japanese Journal of nuclear medicine
Volume27
Number6
Page649-654
Year/Month1990/6
ArticleReport
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractSequential measurements of local cerebral glucose metabolism were performed in a case with Creutzfeldt-Jakob disease. The diagnosis was based on the characteristic clinical symptoms and EEG. Cerebral glucose metabolism (CMRGlc) was measured by positron emission tomography (PET) and 18F-fluorodeoxyglucose. CMRGlc was decrsased to about 45% of the normal value. At that time, X-ray CT revealed little brain strophy. The decrease of CMRGlc was prominent in cerebral cortices, but the metabolic decrease was slight in striatal body, cerebellum, and brainstem. The motor cortex and occipital lobe showed relatively preserved metabolism among the crebral cortices. Six months after the first PET measurement, X-ray CT showed marked brain atrophy. Decrease of cerebral glucose metabolism advanced furthermore. However, the progress of the decrease was relatively small in the basal ganglia, brainstem, and cerebellar nucleus. These findings differ from the findings that was known by pathological study. These results suggest that measurement of CMRGlc by PET is useful for the early detection and for understanding of the pathophysiology of this disease.
PracticeClinical medicine
KeywordsCreutzfeldt-Jakob disease, Cerebral glucose metabolism, Positron emission tomography.

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