| Japanese |
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| Title | 133Xeクリアランス法による冠血流予備能の評価 - ジピリダモール負荷による検討 - |
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| Subtitle | 《原著》 |
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| Authors | 片平敏雄*, 杉原洋樹*, 志賀浩治*, 中川達哉*, 窪田靖志*, 稲垣末次*, 川田公一*, 中村隆志*, 東秋弘*, 古川啓三*, 朝山純*, 勝目紘*, 中川雅夫* |
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| Organization | *京都府立医科大学第二内科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 6 |
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| Page | 639-647 |
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| Year/Month | 1990/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」虚血性心疾患における局所心筋血流動態を評価する目的で, 133Xeクリアランス法により局所心筋血流量(r-MBF)および冠血流予備能を算出し, 冠動脈造影所見と対比検討した. 狭心症22名と胸痛症候群9名を対象とし, 安静時およびジピリダモール負荷時(13名)に133Xeを冠注しr-MBFを測定した. 正常灌流域の安静時r-MBFは平均69mｌ/100g/minで, pressure rate productと相関(r=0.711)し, 心筋血流は需要と供給の保たれた関係にあると考えられた. 高度狭窄部灌流域では, 安静時すでにr-MBFの低下を認めた. ジピリダモール負荷により正常灌流域のr-MBFは平均2.5倍に増加したが, 50-75%狭窄部灌流域では1.9倍, 90%以上の高度狭窄灌流域では1.3倍であり狭窄度の増加に伴い冠血流予備能の低下が明らかであった. 133Xeクリアランス法はr-MBFの実測が容易で, 種々の負荷による変化を定量的に評価可能な有用な方法と考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Ischemic heart disease, Myocardial blood flow, Dipyridamole, Xenon-133 clearance method. |
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| English |
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| Title | Regional Myocardial Blood Flow Measurements in Resting and Dipyridamole Induced Vasodilative State by Xenon-133 Clearance Method |
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| Subtitle | - Original Articles - |
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| Authors | Toshio KATAHIRA, Hiroki SUGIHARA, Koji SHIGA, Tatsuya NAKAGAWA, Yasushi KUBOTA, Suetsugu INAGAKI, Koichi KAWATA, Takashi NAKAMURA, Akihiro AZUMA, Keizo FURUKAWA, Jun ASAYAMA, Hiroshi KATSUME, Masao NAKAGAWA |
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| Organization | Second Department of Medicine, Kyoto Prefectural University of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 6 |
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| Page | 639-647 |
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| Year/Month | 1990/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Myocardial imaging with Xenon-133 and a gamma camera was employed to evaluate the relationship between angiographically demonstrated coronary artery stenosis and regional myocardial blood flow (r-MBF) in 22 patients with ischemic heart disease and 9 control subjects. After a left anterior oblique cineangiogram was obtained, the cinecamera was replaced by the mobile gamma camera in the same plane and location over the precordium of patients. Then, 370 MBq (10 mCi) of 133Xe was injected into the left coronary artery as a bolus. After the first measurement of r-MBF in resting state, a second injection was made 3 minutes after intravenous injection of 0.56 mg/kg of dipyridamole for 4 minutes. The r-MBF in different regions of the heart was calculated by Kety formula. Coronary flow reserve (CFR) was defined the rMBF ratio between resting and dipyridamole induced vasodilative state. In the resting state, good correlation (r=0.711) was observed between pressure rate product and the r-MBF at the areas perfused by non stenotic vessels. The r-MBF of the areas perfused by severe stenotic vessels (>90%) was smaller than that of the areas perfused by non stenotic vessels, however there was overlapping of flow. In the dipyridamole induced vasodilative state, the r-MBF of the areas perfused by intact vessels increased approximately 2.4 times of the resting state, and showed good correlation with pressure rate product. In contrast, the r-MBF of the areas perfused by stenotic vessels did not correlate with pressure rate product, but depended on the degrees of coronary stenosis (50-75% stenosis; 1.9 times, >90% stenosis; 1.3 times, respectively). In conclusion, Xenon-133 clearance method is useful to evaluate the relationship among tissue flow rates, anatomical coronary stenosis and hemodynamics. |
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| Practice | Clinical medicine |
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| Keywords | Ischemic heart disease, Myocardial blood flow, Dipyridamole, Xenon-133 clearance method. |
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