| Japanese |
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| Title | 99mTc-HMPAOによるacetazolamide負荷前後脳血流SPECT |
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| Subtitle | 短報 |
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| Authors | 松田博史*, 東壮太郎**, 絹谷啓子**, 辻志郎*, 隅屋寿*, 久田欣一*, 山下純宏** |
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| Organization | *金沢大学医学部核医学科, **脳神経外科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 5 |
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| Page | 485-492 |
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| Year/Month | 1990/5 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 脳循環予備能を短時間に評価する目的で99mTc-HMPAOによるacetazolamide負荷前後脳血流SPECT法を開発した. まず, 99mTc-HMPAO 555MBq (15mCi) を投与し, その3分後から第1回目のSPECTデータ収集を13.5分間行う. この1回目の収集開始と同時にacetazolamide 1gを静注する. 収集終了直後に99mTc-HMPAO 925MBq (25mCi) を追加投与し, その3分後より2回目のデータ収集を10分間行う. 2回目の収集より得られた再構成像から1回目のそれを, 収集時間の補正後差し引くことにより薬剤負荷時の脳血流SPECT像を得ることができ, 1回目の収集から得られた負荷前の脳血流SPECT像と比較することが可能である. また, 負荷前後での脳血流量の局所変化率を求め得る. 本法では全検査時間を約30分に抑えることができ, 薬剤負荷前後の脳血流像を1回の検査で評価することが可能なため臨床的有用性が高い. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-HMPAO, SPECT, Acetazolamide, Regional cerebral blood flow |
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| English |
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| Title | Brain Perfusion SPECT Imaging before and during the Acetazolamide Test Using 99mTc-HMPAO |
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| Authors | Hiroshi MATSUDA*, Sotaro HIGASHI**, Keiko KINUYA*, Shiro TSUJI*, Hisashi SUMIYA*, Kinichi HISADA*, Junkoh YAMASHITA** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurosurgery, Kanazawa University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 5 |
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| Page | 485-492 |
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| Year/Month | 1990/5 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A new method using brain perfusion 99mTc-HMPAO SPECT imaging was developed for evaluating cerebral perfusion reserve by the acetazolamide test with a short period. The first SPECT study was carried out for 13.5min to obtain SPECT images at the resting state after 3min postinjection of 555MBq (15mCi) of 99mTc-HMPAO. At the same time as the start of the first SPECT study, 1g of acetazolamide was intravenously injected. Immediately after the stop of the 1st SPECT study, 925MBq (25mCi) of 99mTc-HMPAO from the same vial as in the first study was additionally injected. Three minutes later the second SPECT study was carried out for 10min. After reconstruction the tomographic images in the first study were subtracted from the images in the second study to obtain those during the acetazolamide test after correction of the time differences in data acquisition between the two studies. This subtraction technique gives independent brain perfusion SPECT images before and during the acetazolamide test. Besides, the regional flow changes during the test were quantitatively analyzed. In conclusion this method seems to be practically useful for evaluating regional brain perfusion before and during drug treatments as a consecutive study with a short period of approximately 30min. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-HMPAO, SPECT, Acetazolamide, Regional cerebral blood flow |
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