| Japanese |
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| Title | 99mTC-HMPAOエロソールの肺内クリアランス |
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| Subtitle | 原著 |
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| Authors | 川上憲司*, 富永滋**, 高木寛***, 森豊*, 後藤英介*, 岩村晃*, 島田孝夫**** |
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| Authors(kana) | |
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| Organization | *東京慈恵会医科大学放射線科, **順天堂大学浦安病院内科, ***東京慈恵会医科大学柏病院内科, ****東京慈恵会医科大学第三内科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 5 |
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| Page | 451-457 |
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| Year/Month | 1990/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 脂溶性物質, 99mTc-HMPAOを用いたエロソール吸入肺シンチグラフィを施行し, 正常人6名, 種々肺疾患18名を対象として, 肺内における動態について検討した. 99mTc-HMPAOクリアランスのfast phase (T 1/2) は正常人で3.75±2.22secであった. 水溶性エロソールでは, fast phaseは出現しなかった. 99mTc-HMPAOが経細胞性に肺上皮を透過し, 血液によりクリアーされていることを示す. slow phaseについては疾患例を対象に, 水溶性エロソールと対比したが, クリアランス時間に差異を認めた. 99mTc-HMPAO吸入法は, 換気と同時に血流分布の評価にも利用可能と思われる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Aerosol clearance, Lipophilic substance, 99mTc-HMPAO, 99mTc-DTPA, 123I-IMP |
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| English |
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| Title | Pulmonary Clearance of 99mTc-HMPAO Aerosol |
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| Subtitle | Original Articles |
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| Authors | Kenji KAWAKAMI*, Shigeru TOMINAGA**, Hiroshi TAKAGI***, Yutaka MORI*, Eisuke GOTOU*, Akira IWAMURA*, Takao SHIMADA**** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Jikei University School of Medicine, **Department of Medicine, Juntendo University school of Medicine, ***Department of Medicine, Kashiwa Hospital, Jikei University School of Medicine, ****Third Department of Medicine, Jikei University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 5 |
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| Page | 451-457 |
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| Year/Month | 1990/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The clearance rate of inhaled aerosols of a lipophilic substance, 99mTc-HMPAO (Hexamethyl propylene amine oxime) was studied and compared to that of hydrophilic substances in 6 normal volunteers and 18 patients with lung diseases. The subject in sitting Position inhaled a single deep breath of 99mTc-HMPAO aerosols, and held his breath about 30 sec. Then he continued to breath aerosols again for about 3 min. Radioactivity rapidly falls down during breath holding, to about 60% of the peak value (fast phase) , with T 1/2 of 3.75+-2.22 sec in 6 normal volunteers. This rapid phase was not appeared in hydrophilic aerosols with 99mTc-DTPA and 99mTc-pertechnetate and in lipophilic aerosol with 123I-IMP aerosol. The clearance of residual activity of 99mTc-HMPAO was slow with T 1/2 of 17.4+-4.0min. The T 1/2 of 99mTc-DTPA, 99mTc-pertechnetate and 123I-IMP were 50.2+-20.9min, 11.4+-4.3, and 62.5+-20.8min respectively. 99mTc-HMPAO may cross transcellularly using the whole alveolar surface. The clearance of aerosols in the fast phase is rapid and depend on the regional perfusion. On the other hand, hydrophilic aerosol pass by an intercellular pathway and the clearance will be diffusion limited. As conclusion, inhalation study of 99mTc-HMPAO might be a new method to evaluate perfusion following ventilation study. |
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| Practice | Clinical medicine |
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| Keywords | Aerosol clearance, Lipophilic substance, 99mTc-HMPAO, 99mTc-DTPA, 123I-IMP |
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