| Japanese |
|---|
| Title | 131I標識抗CEAおよび131I標識抗CA19-9モノクローナル抗体カクテル (IMACIS-1) を用いたイムノシンチグラフィの臨床的検討 - 第II相治験結果報告 - |
|---|
| Subtitle | 原著 |
|---|
| Authors | 佐々木康人1, 井上登美夫1, 織内昇1, 三橋紀夫2, 永井輝夫2, 五十嵐均3, 辻野大二郎4, 高橋利明4, 榊徳市5, 岡崎篤6, 安藤俊雄6, 前原忠行6, 杉山純夫7, 鈴木良彦7, 綿貫達夫8, 中島哲夫9 |
|---|
| Authors(kana) | |
|---|
| Organization | 1群馬大学医学部核医学教室, 2放射線医学教室, 3中央放射線部, 4聖マリアンナ医科大学第三内科, 5放射線部, 6関東逓信病院放射線科, 7国立高崎病院放射線科, 8綿貫病院, 9埼玉県立がんセンター放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 27 |
|---|
| Number | 4 |
|---|
| Page | 349-362 |
|---|
| Year/Month | 1990/4 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」 131I標識抗CEAモノクロール抗体F (ab')2および131I標識抗CA19−9モノクローナル抗体F (ab')2のカクテル (IMACIS-1) によるイムノシンチグラフィの臨床的応用を試み, その安全性および臨床的有用性を検討した. 対象は, IMACIS-1イムノシンチグラフィを施行した6施設35例の悪性腫瘍患者である. IMACIS-1投与前後の心拍数, 血圧, 体温, 呼吸数には有意の変化は認められなかった. また, 血液学的検査所見, 尿所見, 血液生化学検査所見においてもIMACIS-1投与後に臨床上問題となる変化は認められなかった. IMACIS-1投与後IgG, IgMヒト抗マウス抗体および血中IgEの有意の上昇はみられなかった. 施設ごとの判定を集計した症例別陽性率は31/35 (89%) , 病巣別陽性率は39/53 (74%) であった. なお重篤な副作用は1例も認められなかった. 以上より, IMACIS-1によるイムノシンチグラフィは, 安全かつ有用な検査法と判断した. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Immunoscintigraphy, Monoclonal antibody, IMACIS-1 |
|---|
| English |
|---|
| Title | Clinical Evaluation of Immunoscintigraphy with 131I Anti-CEA and 131I anti-CA19-9 Monoclonal Antibody Cocktail (IMACIS-1) - Report of the Phase II Study - |
|---|
| Subtitle | |
|---|
| Authors | Yasuhito SASAKI1, Tomio INOUE1, Noboru ORIUCHI1, Norio MITSUHASHI2, Teruo NAGAI2, Hitoshi IGARASHI3, Daijirou TSUJINO4, Toshiaki TAKAHASHI4, Tokuichi SAKAKI5, Atsushi OKAZAKI6, Toshio ANDO6, Tadayuki MAEHARA6, Sumio SUGIYAMA7, Yoshihiko SUZUKI7, Tatsuo WATANUKI8, Tetsuo NAKAJIMA9 |
|---|
| Authors(kana) | |
|---|
| Organization | 1Department of Nuclear Medicine, Gunma University, School of Medicine, 2Department of Radiology, Gunma University, School of Medicine, 3Division of Diagnostic Radiology, Gunma University, School of Medicine, 4The Third Department of Internal Medicine, St. Marianna University, School of Medicine, 5Division of Diagnostic Radiology, St. Marianna University, School of Medicine, 6Department of Radiology, Kantoteishin Hospital, 7Department of Radiology, Takasaki National Hospital, 8Watanuki Hospital, 9Division of Radiology, Saitama Cancer Institute |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 27 |
|---|
| Number | 4 |
|---|
| Page | 349-362 |
|---|
| Year/Month | 1990/4 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] The clinical trials of immunoscintigraphy with a cocktail of 131I anti CEA monoclonal antibody F (ab')2 and 131I anti CA19-9 monoclonal antibody F (ab')2 (IMACIS-1) were performed to evaluate the safety and clinical usefulness. Thirty-five patients with proven cancer in six hospitals were examined in the phase two study. No significant changes of the heart rates, temperature, blood pressure, respiratory rates and clinical laboratory data were observed after i. v. IMACIS-1. Significant elevation of HAMA and IgE values in serum were not shown. Positive scintigrams which were interpreted by each hospital were obtained in 31/35 (89%) patients and in 39/53 (74%) lesions. The safety and clinical usefulness of immunoscintigraphy with IMACIS-1 were proven in the phase two study. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Immunoscintigraphy, Monoclonal antibody, IMACIS-1 |
|---|