| Japanese |
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| Title | FDGポジトロンCTを用いた心筋viabilityの評価 - 糖負荷と空腹時画像の比較 - |
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| Subtitle | 研究速報 |
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| Authors | 庭山博行*, 吉田勝哉*, 加賀谷秋彦*, 氷見寿治*, 増田善昭*, 稲垣義明*, 伊藤裕**, 植松貞夫**, 今関恵子***, 有水昇*** |
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| Authors(kana) | |
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| Organization | *千葉大学医学部第三内科, **放射線部, ***放射線科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 3 |
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| Page | 285-288 |
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| Year/Month | 1990/3 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 ブドウ糖50g経口負荷前後で心筋FDG画像およびFDG局所取り込み率の変化を検討することにより, 心筋viabilityの評価を試みた. 冠動脈に病変のない大動脈弁弁膜症ではFDG取り込みは, 空腹・糖負荷時とも一様で, 糖負荷による増加率も一様であった. 急性前壁梗塞では, 前壁部は空腹時, 健常部よりFDG取り込みが多いが, 糖負荷による増加率は健常部より小で画像上は鏡面像をなした. 左室瘤を伴う陳旧性前壁梗塞では空腹・糖負荷時とも前壁部はFDG取り込みが少なく, 糖負荷による増加もほとんどなく, 画像上は同様の像であった. 以上により梗塞部位と健常部位でブドウ糖負荷によるFDG画像とFDG局所取り込み率の変化を比較することで, 心筋viabilityの評価が可能と思われた. 「I. はじめに」 近年Positron Emission Tomography (PET) の開発に伴い, 心筋viabilityの評価に糖代謝の指標である18F-fluorodeoxyglucose (FDG) の利用が注目されている. |
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| Practice | 臨床医学：一般 |
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| Keywords | FDG, Positron emission tomography, Glucose loading image, Fasting image, Myocardial viability |
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| English |
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| Title | PET Assessment of Myocardial Viability with Glucose Loading and Fasting FDG Images |
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| Subtitle | |
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| Authors | Hiroyuki NIWAYAMA*, Katsuya YOSHIDA*, Akihiko KAGAYA*, Toshiharu HIMI*, Yoshiaki MASUDA*, Yoshiaki INAGAKI*, Yutaka ITO**, Sadao UEMATSU**, Keiko IMAZEKI***, Noboru ARIMIZU*** |
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| Authors(kana) | |
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| Organization | *Third Department of Internal Medicine, **Division of Radiology, ***Department of Radiology, Chiba University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 3 |
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| Page | 285-288 |
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| Year/Month | 1990/3 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Positron emission tomography (PET) offers the potential capability of evaluating tissue viability. We have studied the changes of myocardial F-18 deoxyglucose (FDG) uptake with glucose loading. In a fasting state (for at least 5 hours) and in a glucose loading state (50g glucose orally one hour before the study) FDG (74-148 MBq) PET studies were performed for 50-60 minutes in 3 cases. 2 were subjects with anterior myocardial infarction (MI) including one with a ventricular aneurysm (case 1) , one with a recent MI (case 2). One was a subject of aortic valvular disease without coronary lesions (case 3). Arterial input function (Ca (t) ) and myocardial activity (Cm (t) ) were derived from the regions of interest (ROI) on the left atrium and from multiple ROI's circumferentially about the myocardium. Net extraction, FU (Fractional Uptake) =Cm (T) / ∫TO Ca (t) dt, were calculated. Normal segment (N) showed an increase in FU with glucose loading, but the ischemic segment showed no increase (case 1) or a lower increase (case 2) relative to N. This study shows that the increase in FU with glucose loading suggests the persistence of viable myocardium. In conclusion, myocardial viability may be evaluated by comparing FDG images in a glucose loading state with those in a fasting state. |
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| Practice | Clinical medicine |
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| Keywords | FDG, Positron emission tomography, Glucose loading image, Fasting image, Myocardial viability |
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