| Japanese |
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| Title | N-isopropyl-p-iodoamphetamineの肺集積に関する実験的研究 |
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| Subtitle | 短報 |
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| Authors | 小須田茂*, 河原俊司**, 石橋章彦**, 田村宏平**, 久保敦司***, 橋本省三*** |
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| Organization | *東京都立駒込病院放射線診療科, **国立大蔵病院放射線科, ***慶応義塾大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 2 |
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| Page | 149-153 |
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| Year/Month | 1990/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 Wister系雄性ラットに125I-IMPを投与し, ミクロオートラジオグラフィを施行してIMPの肺内集積分布の解析を行った. その結果, 尾静脈投与後1分の正常ラット肺所見は毛細血管, 肺胞中隔を含む間質に高濃度分布がみられ, 肺胞内には濃度分布が認められなかったのに対し, 10Gy 照射肺および非照射肺の尾静脈投与後24時間の肺所見は肺胞内に濃度分布を明瞭に認めた. しかし, 照射肺と非照射肺の濃度分布の差は大きくなかった. 「I. はじめに」 123I-IMPは初回循環で脳組織よりも肺組織に高率に集積することが知られているが, 123I-IMPの肺組織内集積機序は未だ正確に解明されていない. 今回, われわれはWisterラットを用いて125I-IMPによるミクロオートラジオグラフィを施行し, IMPの肺集積機序に関していくつかの知見を得たので報告する. 「II. 方法」 実験動物としてWister系雄性ラット8週齢2匹を用いた. そのうち, 1匹に左肺へ10Gy X線照射を行い, 4週後にオートラジオグラフィを行った. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl-p-iodoamphetamine, Microautoradiography, Lung metabolism, Endothelial cell, Capillary-alveolar barrier |
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| English |
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| Title | Experimental Study on N-Isopropyl-p-Iodoamphetamine Lung Uptake |
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| Subtitle | Short Communication |
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| Authors | Shigeru KOSUDA*, Shunji KAWAHARA**, Akihiko ISHIBASHI**, Kohei TAMURA**, Atsushi KUBO***, Shozo HASHIMOTO*** |
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| Organization | *Department of Radiology, Tokyo Metropolitan Komagome Hospital, **Department of Radiology, Okura National Hospital, ***Department of Radiology, Keio University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 2 |
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| Page | 149-153 |
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| Year/Month | 1990/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Experimental study on N-isopropyl-p-iodoamphetamine lung uptake was performed by means of analyzing microautoradiography obtained by administering 125I-IMP to Wister male rats. In the normal rat lung at one minute after the intravenous injection of 125I-IMP, there is increased grain density in the interstitial space including the capillary lumen and interalveolar septum, but not in the alveolar space. On the other hand, at 24 hours after the intravenous injection, increased grain density was noted in the alveolar space of the rat lungs which had received a dose of 10Gy to the unilateral one. But, definite difference was not found in grain density between the irradiated and non-irradiated lung. The results indicate that part of IMP which was taken up by the endothelial cell is capable of passing through capillaryalveolar barrier. |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl-p-iodoamphetamine, Microautoradiography, Lung metabolism, Endothelial cell, Capillary-alveolar barrier |
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