| Japanese |
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| Title | I-123Metaiodobenzylguanidine (MIBG) 心筋像による労作性虚血状態における交感神経機能の評価 |
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| Subtitle | 原著 |
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| Authors | 田中健*, 相澤忠範*, 加藤和三*, 小笠原憲*, 佐久間徹*, 桐谷肇*, 広坂朗*, 五十嵐正樹* |
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| Organization | *心臓血管研究所 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 2 |
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| Page | 143-147 |
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| Year/Month | 1990/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 I-123Metaiodobenzylguanidine (MIBG) 心筋像を用いて労作性虚血状態における交感神経機能を冠動脈に有意病変を有する労作性狭心症18例で検討した. 負荷Tl-201心筋像に明確な虚血領域を認める5例では, まず安静時にMIBGを投与し安静時MIBG心筋像を撮像した. その後運動負荷を開始し, 狭心症状出現後さらに3分間負荷を加え, その後にもう一度撮像した. 安静時MIBG心筋像と負荷後MIBG心筋像に差を認めなかった. 13例では運動負荷中の症状出現時に同時にTl-201とMIBGを投与した. Tl-201取り込み部位のMIBG心筋像の欠損を6例 (46%) で認めた. 労作性虚血では交感神経末梢においてMIBGの放出は亢進しないが, MlBGの取り込み低下が生じると考えられた. したがって労作性虚血領域の交感神経は刺激されておらず, 交感神経末梢におけるノルエピネフリン摂取率が抑制されていると推定された. |
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| Practice | 臨床医学：一般 |
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| Keywords | I-123 metaiodobenzylguanidine (MIBG) myocardial SPECT images, Sympathetic nervous function, Angina pectoris |
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| English |
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| Title | Study of Sympathetic Nervous Function under Effort Induced Ischemia in Patients with Angina Pectoris with I-123 Metaiodobenzylguanidine (MIBG) Myocardial SPECT Images |
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| Subtitle | Original Articles |
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| Authors | Takeshi TANAKA, Tadanori AIZAWA, Kazuzo KATO, Ken OGASAWARA, Toru SAKUMA, Hajime KIRIGAYA, Akira HIROSAKA, Masaki IGARASHI |
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| Authors(kana) | |
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| Organization | The Cardiovascular Institute |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 2 |
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| Page | 143-147 |
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| Year/Month | 1990/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] I-123metaiodobenzylguanidine (MIBG) is a norepinephrine analog, which can be used to study the sympathetic nervous function of the heart. With MIBG myocardial SPECT images sympathetic nervous function under effort induced ischemia were studied in 18 patients with significant coronary artery lesions. In 5 patients with effort induced ischemic region in stress Tl-201 myocardial images rest MIBG images were collected and then exercise stress test was performed. Patients continued exercising for 3 minutes after onset of symptom. Post-stress MIBG images were collected. Definite ischemic region was noted in stress Tl-201 myocardial images, however no differences were noted between rest and poststress MIBG images. These results suggested that exercise induced ischemia did not enhance release of uptaken MIBG. In 13 patients with significant coronary artery lesions symptom-limited exercise stress test was performed MIBG and Tl-201 were simultaneously injected at onset of symptom and patients continued exercising for an additional one minute. In 6 cases (46%, 6/13) MIBG defects with Tl-201 uptake were noted. These results showed that exercise induced ischemia depressed net MIBG uptake and that sympathetic nervous function (MIBG images) may be more sensitive to ischemic damage than muscle (Tl-201 images) . It is suggested that exercise induced ischemia depressed reuptake of norepinephrine at sympathetic nervous endings. MIBG myocardial SPECT images may be useful for evaluating sympathetic nervous function under ischemia. |
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| Practice | Clinical medicine |
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| Keywords | I-123 metaiodobenzylguanidine (MIBG) myocardial SPECT images, Sympathetic nervous function, Angina pectoris |
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