| Japanese |
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| Title | 因子分析によるマレイン酸負荷ラットにおける99mTc-DMSAの漏出に関する研究 |
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| Subtitle | 原著 |
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| Authors | 小出治敏*, 米倉義晴*, 小西淳二* |
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| Organization | *京都大学医学部附属病院放射線核医学科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 2 |
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| Page | 139-142 |
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| Year/Month | 1990/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 マレイン酸はFanconi syndromeに似た症状を引き起こすnephrotoxinとして知られ, またクエン酸回路の阻害剤であることもよく知られている. われわれは腎臓検査に使用されている放射性医薬品であるI-131 orthoiodohippurate (131I-OIH) Tc-99m dimercaptosuccinic acid (99mTc-DMSA) の尿中排泄が血中のアミノ酸ならびにその代謝産物とどのように相関するのかを, マレイン酸を負荷したラットを用いて調べた. その結果, 131I-OIHの尿中排泄率はphenylalanineと高い相関を示し, 131I-OIHが生体内でアミノ酸に類似した挙動をとることが示唆された. 一方, 99mTc-DMSAの尿中排泄率はあまり相関を示さず, はっきりした解釈はできなかったが, glutamine代謝との関連が推定された. 腎臓はserineの合成をはじめ, アミノ酸代謝に深くかかわっていることが知られており, さらに薬物代謝にも関与する臓器であり, 腎臓による99mTc-DMSAの摂取はアミノ酸代謝や薬物代謝の一面を反映するものかもしれない. |
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| Practice | 臨床医学：一般 |
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| Keywords | 131I-orthoiodohippurate (131I-OIH) , 99mTc-dimercaptosuccinic acid (99mTc-DMSA) , Maleate, Fanconi syndrome |
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| English |
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| Title | A Study of Renal Leak of 99mTc-DMSA in Maleate-Treated Rats by Factor Analysis |
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| Subtitle | Original Articles |
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| Authors | Harutoshi KOIDE, Yoshiharu YONEKURA, Junji KONISHI |
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| Authors(kana) | |
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| Organization | Department of Radiology and Nuclear Medicine, Kyoto University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 2 |
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| Page | 139-142 |
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| Year/Month | 1990/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To elucidate renal leak of 99mTc-dimercaptosuccinic acid (99mTc-DMSA) in maleate-treated rats, plasma amino acid levels and urinary excreted %doses of 99mTc-DMSA and 131I-orthoiodohippurate (131I-OIH) were studied by factor analysis. 0.4mmol of Na-maleate dissolved in 2ml of saline was intraperitoneally injected twice at an interval of 20 hours. Four hours later after second injection, mixture of 99mTc-DMSA and 131I-OIH was injected from tail vein. Urine was collected 15 minutes later to calculate the excretion ratios. Then rats were sacrificed by decapitation and blood samples were taken by cardiac puncture to determine plasma levels of amino acids and their metabolites. Urinary excreted %doses of 99mTc-DMSA were 10.1+-1.3% in control group (n=5) and 10.6+-4.9% in maleatetreated group (n=10) . Of the 10 treated rats, only 2 rats showed clearly increased excretion of 99mTc-DMSA (19.1% and 19.4% respectively and others ranged from 6.2% to 12.0%) . Fifteen variables used for factor analysis consisted of the %doses of two kinds of radiopharmaceuticals and 13 kinds of the data of amino acids analysis. Statistical procedures were as follows. Varimax rotation was performed, two factors were extracted and factor scores for each rat were plotted to obtain scattergram. Interpretation of the results led to a hypothesis that renal leak of 99mTc-DMSA might be relevant to decreased glutamine metabolism. |
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| Practice | Clinical medicine |
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| Keywords | 131I-orthoiodohippurate (131I-OIH) , 99mTc-dimercaptosuccinic acid (99mTc-DMSA) , Maleate, Fanconi syndrome |
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