| Japanese |
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| Title | 111In-標識抗ミオシンモノクローナル抗体-Fabイメージングの臨床応用 (第4報) : 急性心筋梗塞における再灌流の影響 |
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| Subtitle | 原著 |
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| Authors | 山田武彦*, 松森昭*, 玉木長良**, 鷹津良樹*, 渡辺祐司**, 米倉義晴**, 遠藤啓吾**, 小西淳二**, 吉田章***, 田巻俊一****, 河合忠一* |
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| Authors(kana) | |
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| Organization | *京都大学医学部第三内科学教室, **核医学教室, ***三菱京都病院, ****武田病院 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 2 |
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| Page | 133-138 |
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| Year/Month | 1990/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 心筋壊死を忠実に描出する, 111In-抗ミオシンモノクローナル抗体イメージングにおいて, 急性心筋梗塞における再灌流の影響を検討した. 急性心筋梗塞30例のうち, 16例で急性期に冠動脈内血栓溶解療法または経皮的冠動脈拡張術が行われ, 再開通が認められた. イメージングは28例 (93%) で陽性であったが, 発症後ごく早期に再灌流に成功し, その後CPKの上昇を認めなかった1例では陰性であった. 急性期に再灌流が成功したが, CPKの上昇を認めた症例では全例で陽性であった. プラナー像3方向にて心筋を15セグメントに分け, 陽性部分の合計を梗塞サイズとし, 再灌流施行群と再灌流非施行群とで比較した結果では, 有意差はなかった. 抗ミオシン抗体の取り込みをスコア化して比較したところ, 再灌流施行群で再灌流非施行群に比し, 有意に高値を示した. 以上より, 冠血流がイメージングに影響を及ぼすことが示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Indium-111 antimyosin, Acute myocardial infarction, Reperfusion, Percutaneous transluminal coronary angioplasty |
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| English |
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| Title | Clinical Trial of 111In-Antimyosin Antibody Imaging : (4) Effect of Reperfusion in Acute Myocardial Infarction |
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| Subtitle | Original Articles |
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| Authors | Takehiko YAMADA*, Akira MATSUMORI*, Nagara TAMAKI**, Toshiki TAKATSU*, Yuji WATANABE**, Yoshiharu YONEKURA**, Keigo ENDO**, Junji KONlSHI**, Akira YOSHIDA***, Shunichi TAMAKI****, Chuichi KAWAI* |
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| Authors(kana) | |
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| Organization | *The Third Division, Department of Internal Medicine, **Department of Nuclear Medicine, Kyoto University Faculty of Medicine, ***Mitsubishi Kyoto Hospital, ****Takeda Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 2 |
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| Page | 133-138 |
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| Year/Month | 1990/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Effects of reperfusion by intra-coronary thrombolysis (ICT) or percutaneous transluminal coronary angioplasty (PTCA) on the myocardial imaging using 111In-labeled antimyosin monoclonal antibody Fab (In-AM) were studied. Reperfusion by ICT or PTCA was done in 16 patients (reperfusion group) and recanalization was seen in 14. Positive images were obtained in 28 of 30 patients (93%) with acute myocardial infarction (onset to imaging : 9.9+-9.8 days) . Among the reperfusion group, one patient in whom PTCA was done early after the onset of chest pain and CPK did not elevate showed no significant uptake of radioactivity at cardiac region, while other 15 patients with elevation of CPK demonstrated positive images. Planar images (anterior, left anterior oblique 45°, left lateral) were divided into 15 segments and infarct size (antimyosin-segment) was determined by sum of positive segments on each image. There were no significance between the infarct size in the reperfusion group (7.2+-2.9) and that in the nonreperfusion group (6.9+-3.4) . Intensity of the accumulation of radioactivity in each image was classified into 5 grades by comparison with uptake of the liver (antimyosin-score) . Reperfusion group demonstrated high intensity compared with non-reperfusion group (2.6+-0.7 vs. 2.0+-0.4 ; p<0.05) . Thus, In-AM imaging may be influenced by coronary blood flow, which should be taken into consideration in the interpretation of In-AM imaging. |
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| Practice | Clinical medicine |
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| Keywords | Indium-111 antimyosin, Acute myocardial infarction, Reperfusion, Percutaneous transluminal coronary angioplasty |
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