| Japanese |
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| Title | 肥大型心筋症患者におけるdipyridamoleの心筋灌流動態および心機能に及ぼす効果 |
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| Subtitle | 原著 |
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| Authors | 木原和生* |
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| Authors(kana) | |
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| Organization | *久留米大学医学部第三内科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 2 |
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| Page | 107-115 |
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| Year/Month | 1990/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 肥大型心筋症 (HCM) に対し, 冠細小動脈を選択的に拡張するとされるジピリダモール (DP) 150mg/日を2週間内服投与し, その治療効果を検討した. 対象は正常冠動脈を有するHCM 20例で, DP投与後, 血圧は有意に低下したが心拍数の変化はなかった. 運動負荷Tl心筋シンチでは, washout rateの有意な増加と中隔部での一過性灌流欠損の消失がみられ, 運動負荷心プールシンチでは安静時の左室駆出分画と最大充満速度の有意な増加がみられた. このほか, 自覚症状の改善, 心胸郭比の減少, 運動耐容能の増加, ホルター心電図での不整脈の減少を認めた. 以上のように, DPによりHCMの心筋灌流が改善し, 心筋虚血の発生が防止され, さらに後負荷軽減作用が加わり臨床像を改善したと考えられ, DPはHCMの有用な治療薬であることが示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Hypertrophic cardiomyopathy, Oral dipyridamole, Thallium-201 myocardial imaging, Washout rate, RI angiography |
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| English |
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| Title | Therapeutic Effects of Oral Dipyridamole on Myocardial Perfusion and Left Ventricular Function in Patients with Hypertrophic Cardiomyopathy |
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| Subtitle | Original Articles |
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| Authors | Kazuo KIHARA |
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| Authors(kana) | |
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| Organization | The Third Department of Medicine, Kurume University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 2 |
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| Page | 107-115 |
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| Year/Month | 1990/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] As myocardial ischemia possibly due to small vessel coronary disease has been reported in hypertrophic cardiomyopathy (HCM) , we investigated therapeutic efficacy of oral dipyridamole (DP) in 20 patients. DP of 150mg/day for 2 weeks significantly increased septal washout rate (39+-14 to 45+-11%) in exercise Tl-201 myocardial imaging, improving reversible defects in 6 patients. The result further supported that small vessel coronary disease could induce myocardial ischemia in HCM. In RI angiography. DP increased ejection fraction (50+-9 to 53+-7%) and peak filling rate (1.9+-0.6 to 2.0+-0.5 sec-1) at rest. DP also improved subjective symptoms, cardiac size and atrial premature beats in Holter monitoring. In exercise test, maximal work load was increased from 7.6+-2.0 to 8.3+-1.4 METS. These observations indicate that oral DP is an useful drug for treatment of HCM, in improving subjective symptoms, left ventricular function, exercise tolerance and arrhythmias, possibly due to beneficial effects on myocardial perfusion and afterload reduction. |
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| Practice | Clinical medicine |
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| Keywords | Hypertrophic cardiomyopathy, Oral dipyridamole, Thallium-201 myocardial imaging, Washout rate, RI angiography |
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