| Japanese |
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| Title | 123I-IMP Brain SPECTのコンパートメントモデル解析 |
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| Subtitle | 研究速報 |
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| Authors | 日向野修一*, 宍戸文男*, 相沢康夫*, 三浦修一*, 村上松太郎*, 犬上篤*, 菅野巖*, 藤田英明*, 上村和夫* |
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| Organization | *秋田県立脳血管研究センター放射線医学研究部 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 1 |
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| Page | 51-54 |
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| Year/Month | 1990/1 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 123I-IMPの脳内動態を明らかにするため, 9例の被検者を対象に, コンパートメントモデル解析を試みた. 血液プールと脳組織の2つのコンパートメントからなるモデルを想定し, 動脈血脂溶分画の時間濃度曲線を入力関数とし, 57分間のSPECT動態測定にて求めた脳組織の蓄積曲線に適合する速度定数 (k1, k2) を算出した. また210分後に遅延像も撮像した. 57分間の動態測定データから算出したk値を用い, 2 コンパートメントモデルにて計算した210分後の脳組織の放射能濃度とその実測値とは良く一致しており, IMPの脳内動態がこのモデルにて良好に近似できると考えられた. IMPの分配定数 (kl/k2比) の平均値は約35と大きく, また, 血流量に依存しなかった. このことは, IMPの早期の脳内分布は脳血流を反映することを示しており, 早期像を用いればmicrosphereモデルにても比較的信頼性の高い血流量の算出が可能と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, SPECT, Compartment model, Cerebral blood flow |
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| English |
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| Title | Compartment Analysis of 123I-IMP Brain SPECT |
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| Subtitle | |
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| Authors | Shuichi HIGANO, Fumio SHISHIDO, Yasuo AlZAWA, Shuichi MIURA, Matsutaro MURAKAMI, Atsushi INUGAMI, Iwao KANNO, Hideaki FUJITA, Kazuo UEMURA |
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| Authors(kana) | |
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| Organization | Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 1 |
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| Page | 51-54 |
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| Year/Month | 1990/1 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To clarify the kinetics of N-isopropyl [123I] piodoamphetamine (IMP) in the brain, 2-compartment analysis was applied for brain SPECT with 57-minute dynamic scan in 9 subjects. The model consisted of blood component and brain tissue component. Two transfer rate constants were defined ; k1 showed the rate from the blood to the brain tissue, and k2 was that of back diffusion. The late scan was performed 210 minutes after the tracer injection. Suitable k values best fitting to the dynamic data were determined for all regions of interest. Predicted regional cerebral activity at 210 minutes using 57-minute dynamic data was well agreed with measured activity. These showed the kinetics of IMP in the brain was well described by the 2-compartment model. The partition coefficient (kl/k2 ratio) was as large as about 35, and almost constant in the various brain structures including hypoperfused areas. These findings indicated that the initial IMP images reflected the reasonable CBF distribution, which gave relatively reliable CBF values even if using microsphere model. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, SPECT, Compartment model, Cerebral blood flow |
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